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Vaccine ; 26(16): 2010-9, 2008 Apr 07.
Artigo em Inglês | MEDLINE | ID: mdl-18342996

RESUMO

In a previous study, signature sequence mutagenesis (SSM) was used to identify a mutant with a disruption of the gene encoding the metabolic factor, dihydrolipoamide dehydrogenase, and that mutant was designated Mg 7. The current study assessed the safety, immunogenicity and efficacy of Mg 7 in comparison to two commercially available vaccines (ts-11 and F) as well as a laboratory vaccine strain, GT5. Intratracheal vaccination of chickens with all four attenuated mutants induced varying levels of protection against intratracheal challenge with virulent Mycoplasma gallisepticum strain R(low). Mg 7 vaccinated chickens rapidly cleared the challenge strain, had lower histopathologic tracheal lesion scores when compared to unvaccinated chickens, and mounted a strong humoral anti-M. gallisepticum-specific IgG response. The IgG levels increased 2- to 3-fold upon R(low) challenge. Mg 7 induced a greater level of protection against intratracheal R(low) challenge than that observed with the other three attenuated strains, as evidenced by a lower recovery of R(low) from tracheas and lower histopathologic lesion scores in tracheas and air sacs. Based on these findings, Mg 7 appears to have good potential as a safe and effective vaccine for the prevention of avian mycoplasmosis.


Assuntos
Vacinas Bacterianas/administração & dosagem , Infecções por Mycoplasma/veterinária , Mycoplasma gallisepticum/imunologia , Doenças das Aves Domésticas/prevenção & controle , Infecções Respiratórias/veterinária , Vacinação , Sacos Aéreos/patologia , Animais , Anticorpos Antibacterianos/sangue , Galinhas , Di-Hidrolipoamida Desidrogenase/genética , Feminino , Mutação , Infecções por Mycoplasma/patologia , Infecções por Mycoplasma/prevenção & controle , Mycoplasma gallisepticum/enzimologia , Mycoplasma gallisepticum/genética , Doenças das Aves Domésticas/patologia , Mucosa Respiratória/patologia , Infecções Respiratórias/patologia , Infecções Respiratórias/prevenção & controle , Traqueia/patologia , Vacinas Atenuadas/administração & dosagem
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