[Digitalisation in Companies: The COVID-19 Pandemic as a Push Factor]. / Digitalisierungsschub in Firmen während der Corona-Pandemie.

This article shows the extent to which companies' investments in digital technologies have increased during the COVID-19 pandemic. Based on a large German company survey conducted by the Institute for Employment Research, the authors examine whether and which companies have invested in different types of digital technologies, how these investments are connected to working from home, and how investments are influenced by the economic situation of companies during the pandemic. The authors also discuss further training activities provided and planned by employers and how those are related to their investments in digital technologies.

Compulsory schooling reforms, education and mortality in twentieth century Europe.

Education yields substantial non-monetary benefits, but the size of these gains is still debated. Previous studies report causal effects of education and compulsory schooling on mortality ranging anywhere from zero to large and negative. Using data from 18 compulsory schooling reforms implemented in Europe during the twentieth century, we quantify the average mortality gain and explore its dispersion across gender, time and countries. We find that more education yields small mortality reductions in the short- and long-run for men. In contrast, women seem to experience no mortality reductions from compulsory schooling reforms.

Cell adhesion molecules in metastatic neuroblastoma models.

Several cell adhesion molecules (CAMs) including selectins, integrins, cadherins and immunoglobulin-like CAMs are involved in leukocyte adhesion especially at sites of inflammation. In cancer cells, these CAMs have been associated with the growth and metastatic behavior in several malignant entities. In this study adhesion of LAN 1 and SK-N-SH neuroblastoma cells to selectins, hyaluronan and endothelial cells were determined under flow conditions. Furthermore cells were injected subcutaneously into wildtype and selectin deficient scid mice and their growth and metastatic behavior were analyzed. Under shear stress SK-N-SH cells firmly adhered to E-selectin-Fc-fusion protein, hyaluronan and endothelial cells, while LAN 1 cells showed less or hardly any adhesive events by comparison. In the SK-N-SH xenograft model metastasis formation was slightly dependent on the expression of selectins, while LAN 1 cells developed metastases completely independent of selectin expression. The different adhesive and metastatic properties of LAN 1 and SK-N-SH cells are reflected by a different expression profile of several CAMs. The results indicate that endothelial selectins are not essential for metastasis formation of human LAN 1 and SK-N-SH cells. However, other CAMs namely CD44, N-cadherin, NCAM and integrins were upregulated or downregulated, respectively, in SK-N-SH and LAN 1 cells and are potential adhesion molecules involved in the metastatic cascade of these cells.

The Gorbachev Anti-Alcohol Campaign and Russia's Mortality Crisis.

Political and economic transition is often blamed for Russia's 40% surge in deaths between 1990 and 1994. Highlighting that increases in mortality occurred primarily among alcohol-related causes and among working-age men (the heaviest drinkers), this paper investigates an alternative explanation: the demise of the 1985-1988 Gorbachev Anti-Alcohol Campaign. Using archival sources to build a new oblast-year data set spanning 1978-2000, we find a variety of evidence suggesting that the campaign's end explains a large share of the mortality crisis - implying that Russia's transition to capitalism and democracy was not as lethal as commonly suggested.