Consistency of maternal cognitions and principles across the first five months following preterm and term deliveries.

The aims of this study were to examine and compare the development of parenting cognitions and principles in mothers following preterm and term deliveries. Parenting cognitions about child development, including thinking that is restricted to single causes and single outcomes (categorical thinking) and thinking that takes into account multiple perspectives (perspectivist thinking), have been shown to relate to child outcomes. Parenting principles about using routines (structure) or infant cues (attunement) to guide daily caregiving have been shown to relate to caregiving practices. We investigated the continuity and stability of parenting cognitions and principles in the days following birth to 5 months postpartum for mothers of infants born term and preterm. All parenting cognitions were stable across time. Categorical thinking increased at a group level across time in mothers of preterm, but not term, infants. Perspectivist thinking increased at a group level for first-time mothers (regardless of birth status) and tended to be lower in mothers of preterm infants. Structure at birth did not predict later structure (and so was unstable) in mothers of preterm, but not term, infants and neither group changed in mean level across time. Attunement was consistent across time in both groups of mothers. These results indicate that prematurity has multiple, diverse effects on parenting beliefs, which may in turn influence maternal behavior and child outcomes.

Clinical research strategies in biotechnology.

Clinical drug development involves many steps and is extremely costly to the sponsoring company. There is intense pressure on sponsors to be faster, more efficient, and less costly. Sponsors also need to be globally oriented in their drug-development processes. There are several ways in which clinical drug development may be done more quickly and at less cost. These strategies include the use of large contract research organizations (CRO) and site management organizations (SMO). Although there is an estimated 2000 CRO worldwide, the use of SMO is quite limited but growing rapidly. Changes in the US Food and Drug Administration (FDA), especially harmonization between its two divisions Center for Biologics Evaluation and Research (CBER) and Center for Drug Evaluation and Research (CDER), and the use of CRO and SMO will make for interesting and challenging times for sponsors.

Imitation of gestures in children is goal-directed.

The view that the motor program activated during imitation is organized by goals was investigated by asking pre-school children to imitate a set of hand gestures of varying complexity that were made by an experimenter sitting in front of them. In Experiments 1 and 3, children reached for the correct object (one of their own ears or one of two dots on a table) but preferred to use the ipsilateral hand. This ipsilateral preference was not observed when hand movements were made to only one ear (Experiment 2), or when movements were directed at space rather than physical objects (Experiment 3). The results are consistent with the notion that imitation is guided by goals and provide insights about how these goals are organized.

Mapping conceptual to spatial relations in visual reasoning.

In 3 experiments, the authors investigated the impact of goals and perceptual relations on graph interpretation when people evaluate functional dependencies between continuous variables. Participants made inferences about the relative rate of 2 continuous linear variables (altitude and temperature). The authors varied the assignments of variables to axes, the perceived cause-effect relation between the variables, and the causal status of the variable being queried. The most striking finding was that accuracy was greater when the slope-mapping constraint was honored, which requires that the variable being queried be assigned to the vertical axis, so that steeper lines map to faster changes in the queried variable. The authors propose that graphs provide external instantiations of intermediate mental representations, enabling people to move from visuospatial representations to abstractions through the use of natural mappings between perceptual and conceptual relations.