Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
Biostatistics ; 11(4): 609-30, 2010 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-20350956

RESUMO

Some methods for the statistical analysis of surface shapes and asymmetry are introduced. We focus on a case study where magnetic resonance images of the brain are available from groups of 30 schizophrenia patients and 38 controls, and we investigate large-scale brain surface shape differences. Key aspects of shape analysis are to remove nuisance transformations by registration and to identify which parts of one object correspond with the parts of another object. We introduce maximum likelihood and Bayesian methods for registering brain images and providing large-scale correspondences of the brain surfaces. Brain surface size-and-shape analysis is considered using random field theory, and also dimension reduction is carried out using principal and independent components analysis. Some small but significant differences are observed between the the patient and control groups. We then investigate a particular type of asymmetry called torque. Differences in asymmetry are observed between the control and patient groups, which add strength to other observations in the literature. Further investigations of the midline plane location in the 2 groups and the fitting of nonplanar curved midlines are also considered.


Assuntos
Bioestatística/métodos , Encéfalo/patologia , Imageamento por Ressonância Magnética/métodos , Esquizofrenia/patologia , Adulto , Algoritmos , Teorema de Bayes , Encéfalo/anatomia & histologia , Feminino , Humanos , Funções Verossimilhança , Masculino , Cadeias de Markov , Modelos Estatísticos , Método de Monte Carlo , Análise de Componente Principal , Distribuições Estatísticas , Propriedades de Superfície
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...