Time-of-flight scatter rejection in x-ray radiography.

Objective.Time-of-flight (TOF) scatter rejection allows for identifying and discarding scattered photons without the use of an anti-scatter grid (ASG). Although TOF scatter rejection was initially presented for cone-beam computed tomography, we propose, herein, to extend this approach to x-ray radiography. This work aims to evaluate with simulations if TOF scatter rejection can outperform ASGs for radiography.Approach.GATE was used to simulate the radiography of a head and a torso and a water cylinder with bone inserts in a system with total timing jitters from 0 ps up to 500 ps full-width-at-half-maximum. The transmission factor of TOF scatter rejection for primary and scattered photons was evaluated as if it were a virtual ASG.Main results.With a total timing jitter of 50 ps, TOF scatter rejection can reach a selectivity of 4.93 with a primary photons transmission of 99%. Reducing the timing jitter close to 0 ps increases the selectivity up to 15.85 for a head and torso radiography, outperforming typical ASGs which usually have a selectivity from 2.5 to 10 with a primary photons transmission from 50% to 70%.Significance.This suggests that TOF scatter rejection may be suitable to replace ASGs in applications requiring lower radiation exposure if sufficiently low timing jitter is achieved.

Time-of-flight computed tomography - proof of principle.

Computed tomography has greatly improved over the last decade, especially through x-ray dose exposure reduction while maintaining image quality. Herein, a new concept is proposed to improve the contrast-to-noise ratio (CNR) by including the time-of-flight (TOF) information of individual photons to obtain further insight on the photon's trajectory and to reject scatter contribution. The proof of the concept relies on both simulation and experimental measurements in a cone-beam computed tomography arrangement. Results show a statistical difference between the TOF of scattered and primary photons exploitable in TOF computed tomography. For a large volume of the size of a human abdomen, a scatter reduction from 296% to 4% is achieved in our simulation setup with perfect timing measurements which yields a 110% better CNR, or a dose reduction by a factor of four. Cup artifacts are also reduced from 24.7% to 0.8%, and attenuation inaccuracies are improved from -26.3% to -0.8%. With 100 ps and 10 ps FWHM timing jitters, respectively 75% and 95% of the scatter contribution can be removed with marginal gains below 10 ps. Experimental measurements confirm the feasibility of measuring statistical differences between the TOF of scattered and primary photons.

The concentration of immunoreactive prostate specific antigen is not decreased in viscous semen samples.

The concentration of immunoreactive prostate specific antigen (PSA) was determined in the seminal plasma of 79 men who were classified into 4 groups according to sperm characteristics: there were 3 groups with low viscosity sperm (normal, large or small volume) and one group with high viscosity and normal volume. PSA concentrations in the group with high viscosity were not significantly different from the group with low viscosity and normal or large volume. PSA was significantly increased only in the "small volume group" (p less than 0.01). These results show that absolute amounts of PSA are not decreased in seminal plasma with high viscosity and therefore are not the cause of abnormal liquefaction of the semen in these patients.