Pedagogically treating topics as having several ways to be addressed: Harmonically varying states of free-edge circular plates.

The paper is mainly concerned with the training of students by treating exercises as having several ways to be addressed. The topic considered herein focuses on the vibrations of a free edge axisymmetric homogeneous circular thin plate excited by a time-periodic source. This topic is prepared using the three analytic methods available (but these are not fully used analytically in the literature) to show the different aspects of the problem: modal expansion, integral formulation, and exact general solution, against which the other models are tested. Several results are provided when the source is localized at the center of the plate to validate the methods with each other, and these are discussed before concluding.

Comparison of three full-field optical measurement techniques applied to vibration analysis.

Digital image correlation, deflectometry and digital holography are some of the full-field optical measurement techniques that have matured in recent years. Their use in vibroacoustic applications is gaining attention and there is a need for cataloging their performance in order to provide, to a broad community of users and potential future users, quantitative and qualitative evaluations of these three approaches. This paper presents an experimental comparison of the three optical methods in the context of vibration measurements, along with classical reference measurements provided by an accelerometer and a laser Doppler vibrometer. The study is carried out on two mechanical structures exhibiting various vibration responses when submitted to an impact.

RNA polymerase backtracking results in the accumulation of fission yeast condensin at active genes.

The mechanisms leading to the accumulation of the SMC complexes condensins around specific transcription units remain unclear. Observations made in bacteria suggested that RNA polymerases (RNAPs) constitute an obstacle to SMC translocation, particularly when RNAP and SMC travel in opposite directions. Here we show in fission yeast that gene termini harbour intrinsic condensin-accumulating features whatever the orientation of transcription, which we attribute to the frequent backtracking of RNAP at gene ends. Consistent with this, to relocate backtracked RNAP2 from gene termini to gene bodies was sufficient to cancel the accumulation of condensin at gene ends and to redistribute it evenly within transcription units, indicating that RNAP backtracking may play a key role in positioning condensin. Formalization of this hypothesis in a mathematical model suggests that the inclusion of a sub-population of RNAP with longer dwell-times is essential to fully recapitulate the distribution profiles of condensin around active genes. Taken together, our data strengthen the idea that dense arrays of proteins tightly bound to DNA alter the distribution of condensin on chromosomes.

Biophysical and structural characterization of mono/di-arylated lactosamine derivatives interaction with human galectin-3.

Combination of biophysical and structural techniques allowed characterizing and uncovering the mechanisms underlying increased binding affinity of lactosamine derivatives for galectin 3. In particular, complementing information gathered from X-ray crystallography, native mass spectrometry and isothermal microcalorimetry showed favorable enthalpic contribution of cation-π interaction between lactosamine aryl substitutions and arginine residues from the carbohydrate recognition domain, which resulted in two log increase in compound binding affinity. This incrementing strategy allowed individual contribution of galectin inhibitor moieties to be dissected. Altogether, our results suggest that core and substituents of these saccharide-based inhibitors can be optimized separately, providing valuable tools to study the role of galectins in diseases.

Quality assessment of combined quantization-shot-noise-induced decorrelation noise in high-speed digital holographic metrology.

this paper discusses on the influence of decorrelation noise induced by quantization and shot-noise when recording digital holograms at very high frame rate. A criterion based on the coherence factor of the hologram phase difference is proposed. The main parameters of interest are the ratio between the reference and the object waves and the sensor dynamics, depending on the photo-electron capacity of pixels. The study is based on a full numerical simulation of the holographic process, which provides useful rules. This leads to define the optimal conditions for recording at very-high frame rate with minimization of the decorrelation noise. Experimental results obtained with frame rate at 50kHz confirm the proposed approach.

Multi-point vibrometer based on high-speed digital in-line holography.

This paper describes a digital holographic setup based on in-line holography and a high-speed recording to get a multipoint vibrometer. The use of a high-speed sensor leads to specificities that enable the in-line configuration to be used. The case of transient vibrations is investigated through a full simulation of the holographic process. The simulation shows that the first instants are critical since distortion may occur, resulting in errors in the phase measurement. Experimental results are provided by exciting an aluminum beam with a transient signal. A comparison with the velocity measured by a pointwise vibrometer is provided. Frequency response functions are extracted and the experimental results confirm the ability of the method to provide full-field contactless measurements at the high-speed time scale evolution of the vibration.

Extraction and analysis of body-induced partials of guitar tones.

Guitar plucked sounds arise from a rapid input of energy applied to the string coupled to the instrument body at the bridge. For the radiated pressure, this results in quasi-harmonic contributions, reflecting the string modes coupled to the body, as well as some transient and quickly decaying components reflecting the excitation of the body modes of the instrument. In order to evaluate the relevance of this transient body sound, a high resolution analysis-synthesis method is described for the extraction of the body-mode contribution from the radiated pressure measured in the near field of the guitar top plate. This analysis scheme is first tested on synthesized signals. Some body-sound emergence indicators are then proposed and computed over a pool of instruments. The influence of the conditions of excitation on the body-sound emergence is investigated, and the instruments categorized according to these objective descriptors. Results show a larger range of body-sound emergence with variations of the plucking position in hand-made guitars compared to industrial instruments. This suggests that these particular hand-made instruments are more sensitive to variations in the control from the player and hence allow a wider range of timbres with respect to the transient coloration of the body modes.

Acoustic signature of violins based on bridge transfer mobility measurements.

This paper is an attempt to solve two problems related to musical acoustics. The first one consists in defining a signature of an instrument, namely, summarizing its vibroacoustical behavior. The second one deals with the existing relationship between the musical sound and the vibroacoustic properties of the instrument body. The violin is the application of this paper. A proposed solution for the first problem consists in an estimation of the bridge transfer mobility and the mean-value of the lateral bridge transfer mobility. The second problem is studied via the comparison between the amplitudes of harmonics, extracted from a glissando audio signal, and the lateral bridge transfer mobility: Both curves exhibit similar features. This is the main result of the paper. This is evidenced by studying the effect of a violin mute on both the lateral bridge transfer mobility and the produced sound. Finally, this is evidenced by successfully identifying which violin is played in an audio recording, using the computation of the Pearson distance between the distribution of the amplitude of harmonics and a database of measured mobilities.

Evaluation of surface acoustic waves on the human skin using quasi-time-averaged digital Fresnel holograms.

This paper proposes a first attempt to visualize and analyze the vibrations induced by a bone-conduction device and propagating at the surface of the skin of a human face. The method is based on a new approach in a so-called quasi-time-averaging regime, resulting in the retrieval of the vibration amplitude and phase from a sequence of digital Fresnel holograms recorded with a high image rate. The design of the algorithm depends on the ratio between the exposure time and the vibration period. The results show the propagation of vibrations at the skin surface, and quantitative analysis is achieved by the proposed approach.

Macro parameters describing the mechanical behavior of classical guitars.

Since the 1960s and 1970s, researchers have proposed simplified models using only a few parameters to describe the vibro-acoustical behavior of string instruments in the low-frequency range. This paper presents a method for deriving and estimating a few important parameters or features describing the mechanical behavior of classical guitars over a broader frequency range. These features are selected under the constraint that the measurements may readily be made in the workshop of an instrument maker. The computations of these features use estimates of the modal parameters over a large frequency range, made with the high-resolution subspace ESPRIT algorithm (Estimation of Signal Parameters via Rotational Invariant Techniques) and the signal enumeration technique ESTER (ESTimation of ERror). The methods are applied to experiments on real metal and wood plates and numerical simulations of them. The results on guitars show a nearly constant mode density in the mid- and high-frequency ranges, as it is found for a flat panel. Four features are chosen as characteristic parameters of this equivalent plate: Mass, rigidity, characteristic admittance, and the mobility deviation. Application to a set of 12 guitars indicates that these features are good candidates to discriminate different classes of classical guitars.

Vibroacoustic characteristics of a gothic harp.

The "gothic" style of harp was popular across most of Europe from the late medieval period to the Renaissance. These harps have a one-piece, longitudinally oriented hardwood soundboard, as opposed to the transverse-oriented bonded softwood structure on a modern instrument. In addition, the one-piece back is flexible, whereas the back of a modern instrument is a rigid molded shell. To study the gothic harp, one was constructed from plans created by the Boston Museum of Fine Arts from a late German model in their collection. The vibrational behaviors of the soundboard and soundbox were measured at various stages of construction. The completed instrument was subjected to modal analysis and radiativity measurements. The sound radiation is dominated by two breathing modes at 188 and 273 Hz, each with strong motion of the back, and modes around 350 Hz. Taken together, these modes function like the A0/T1 resonance pairs seen in the soundboxes of other instruments, and a comparison is made with the guitar. Also observed is that as the frequency increases, radiation is emitted from higher up the soundboard, and from higher soundholes. This feature has been observed in other harps, and is a consequence of the harp family's unique geometry.

Scope of the organocatalysed asymmetric reductive amination of ketones with trichlorosilane.

A highly active organocatalyst has been shown to affect the asymmetric reductive amination of ketones producing both aromatic and aliphatic amines. At 1 mol% catalyst loading, a series of structurally diverse chiral amines were quickly and economically prepared with good enantioselectivity and generally useful yield. The efficient synthesis of the calcimimetic (+)-NPS R-568 (67%, 89% ee) demonstrated the synthetic applicability of this methodology.

Combining carbohydrate substitutions at bioinspired positions with multivalent presentation towards optimising lectin inhibitors: case study with calixarenes.

Carbohydrate derivatisation and glycocluster formation are both known to enhance avidity for lectin binding. Using a plant toxin and human adhesion/growth-regulatory lectins (inter- and intrafamily comparisons) the effect of their combination is examined. In detail, aromatic substituents were introduced at the 2-N or 3'-positions of N-acetyllactosamine and the products conjugated to two types of calix[n]arenes (n = 4, 6) via thiourea-linker chemistry.

The iodosulfonamidation of peracetylated glycals revisited: access to 1,2-di-nitrogenated sugars.

Iodosulfonamidation of peracetylated glycals was investigated using either a combination of N-iodosuccinimide/iodine or iodine chloride as a source of iodonium ion. 1,2-trans- and 1,2-cis-2-deoxy-2-iodo-1-sulfonamido hexoses were, respectively, obtained depending on the reagent system used. Both series of isomers were successfully converted to 1,2-di-nitrogenated compounds, for example, 1-azido-1,2-dideoxy-2-sulfonamido sugars, which are useful intermediates for the synthesis of N-linked glycoproteins or glycoconjugates.

Some characteristics of the concert harp's acoustic radiation.

The way a musical instrument radiates plays an important part in determining the instrument's sound quality. For the concert harp, the soundboard has to radiate the string's vibration over a range of 7 octaves. Despite the effort of instrument makers, this radiation is not uniform throughout this range. In a recent paper, Waltham and Kotlicki [J. Acoust. Soc. Am. 124, 1774-1780 (2008)] proposed an interesting approach for the study of the string-to-string variance based on the relationship between the string attachment position and the operating deflection shapes of the soundboard. Although the soundboard vibrational characteristics determine a large part of the instrument's radiation, it is also important to study directly its radiation to conclude on the origins of the string-to-string variation in the sound production. This is done by computing the equivalent acoustical sources on the soundboard from the far field sound radiation measured around the harp, using the acoustic imaging technique inverse frequency response function. Results show that the radiated sound depends on the correlation between these sources, and the played string's frequency and location. These equivalent sources thus determine the magnitude and directivity of each string's partial in the far field, which have consequences on the spectral balance of the perceived sound for each string.

Asymmetric reduction of ketimines with trichlorosilane employing an imidazole derived organocatalyst.

Organocatalysts for the asymmetric reduction of ketimines are presented that function well at low catalyst loadings providing chiral amines in good yield and enantioselectivity, the latter appearing to be independent of the ketimine substrate geometry.

Influence of wall vibrations on the behavior of a simplified wind instrument.

The issue of the influence of wall vibrations on the behavior of wind instruments is still under debate. The mechanisms of vibroacoustic couplings involved in these vibrations are difficult to investigate, as fluid-structure interactions are weak. Among these vibroacoustic interactions, the present study is focused on the coupling between the internal acoustic field and the mechanical behavior of the duct. For this purpose, a simplified single reed instrument consisting of a brass tube connected to a clarinet mouthpiece has been studied. A theoretical model of coupling between the plane inner acoustic wave and mechanical modes is developed and suggests that in order to obtain measurable effects of wall vibrations, the geometrical parameters of the studied tube have to be unusual compared to that of real instruments. For a slightly oval-shaped and very thin brass tube, it is shown theoretically and experimentally that a coupling between the inner plane acoustic wave and ovalling mechanical modes occurs and results in disturbances of the input impedance, which can slightly affect the tone color of the sound produced. It is concluded that the reported effects are unlikely to occur in real instruments except for some organ pipes.