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Food Chem Toxicol ; 33(4): 265-71, 1995 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-7737600

RESUMO

Tibia dimensions and mechanical properties were determined in White Leghorn cockerels that had been fed from 0.1 to 2.0% niacin as a supplement to standard poultry diets. Four experiments of from 20 to 38 days were conducted. No significant differences due to niacin were found in weight gain, feed consumed or feed:gain ratios. Decreases in the exterior (P < 0.009) and interior (P < 0.015) diameters of the major axes of the tibiae were found at 0.75-2.0% niacin. Exterior (P < 0.005) and interior (P < 0.001) diameters of the minor axes of the tibia were decreased at levels of 0.75 and 1%. Changes occurred in lateral wall thickness of chicks fed 0.75% niacin for 20 days (P < 0.004) and 38 days (P < 0.023) and in anterior wall thickness of 6-month-old chickens fed 1.0% niacin for 28 days (P < 0.001). Ultimate force was decreased in young chicks fed 1.0 and 1.5% niacin (P < 0.014) and 6-month-old White Leghorn chickens fed 1.0% niacin (P < 0.004). The addition of high levels of niacin to chick rations resulted in changes in dimensions, bone strength and susceptibility to fracture.


Assuntos
Niacina/toxicidade , Tíbia/efeitos dos fármacos , Análise de Variância , Animais , Fenômenos Biomecânicos , Galinhas , Ingestão de Alimentos/efeitos dos fármacos , Alimentos Fortificados , Masculino , Niacina/administração & dosagem , Distribuição Aleatória , Tíbia/metabolismo , Tíbia/fisiologia
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