[Differentiated approach to preventive treatment of new cases of tuberculosis in children]. / Differentsirovannyi podkhod k profilakticheskomu lecheniiu detei, vpervye infitsirovannykh tuberkulezom.

The efficiency of various preventive treatment regimens was studied in 330 new cases of childhood tuberculosis by using clinical and laboratory findings and follow-up data. The paper shows it expedient to conduct a comprehensive immunological studies by tuberculin diagnosis and to examine immunity both at the time of infection detection in children and at their follow-ups. Monotherapy by the routine regimen can be performed in low tuberculin-sensitive children without risk factors. Children who have a complex of risk factors need long-term preventive treatment with two tuberculosis controlling agents. When immune responsiveness declines in children, it is necessary to apply pathogenetic agents that possess an immunomodulating effect, which substantially raise the efficiency of preventive treatment.

[Improved technology of chemotherapy of pulmonary tuberculosis complicated by other diseases]. / Sovershenstvovanie tekhnologii khimioterapii tuberkuleza legkikh, otiagoshchennogo soputstvuiushchimi zabolevaniiami.

Ample clinical material obtained in Yakutia was used to study the efficiency of combined treatment in patients with disseminated pulmonary tuberculosis concurrent with gastrointestinal and respiratory diseases. At the same time it was justifiable to employ alternatives to deliver antituberculous agents to the lesion focus (rectal dropwise administration, phono- and photophoresis of isoniazid, endobronchial colloid diluted rifampicin, and activated silver water diluted antituberculous drugs) with additional biophysical exposure. This made this group of patients have much better antituberculous agent intolerance, which increased nonbacterial isolation rates and closed decay cavities as compared with conventional methods for administering antituberculous agents.

[Treatment of tuberculosis patients with massive bacterial excretion]. / Lechenie bol'nukh tuberkulezom legkikh s massivnym bakteriovydeleniem.

A new endobronchial treatment has been developed for patients with destructive pulmonary tuberculosis with massive bacterial excretion, complicated by chronic nonspecific endobronchitis. The treatment includes inhalation therapy with antituberculous drugs dissolved in activated silver water. This treatment of 42 patients has shown more than 2-fold increases in the rate of massive bacterial excretion cessation.

[Use of external laser radiation in patients with infiltrative pulmonary tuberculosis]. / Primenenie naruzhnogo lazernogo oblucheniia u bol'nykh infil'trativnym tuberkulezom legkikh.

A procedure has been developed for the use of semiconductor laser radiation in the combined drug therapy of patients with disseminated infiltrative pulmonary tuberculosis with multiple destructions and massive bacterial excretion, by increasing the number of sessions, which reduces the time of bacterial excretion cessation by 2-4 weeks, decay cavity closure by a months, and hospital treatment by 1.5 months and promotes minimal residual changes in most of them.