[Morphological characteristic of wound healing process in patients with diabetic purulent-necrotic foot lesion treated with oxytocin]. / Morfologicheskaia kharakteristika ranevogo protsessa u bol'nykh s diabeticheskimi gnoino-nekroticheskimi porazheniiami stop pri vozdeistvii oksitotsinom.

Wound healing was studied in 90 patients with "diabetic foot" receiving complex treatment which included oxytocin (40 patients) or did not use it (50 patients). Intraarterial injection or local application of oxytocin resulted in significant differences of wound process characteristics as compared with those ones in control group. The necrobiotic and necrotic changes in the tissues of skin, subcutaneous adipose tissue and skeletal muscles, located within the purulent-necrotic foci, were less expressed. The number of sludged capillaries, as well as of arterioles and venules with the signs of microthrombosis, was significantly decreased. Simultaneously, the regenerative potential of endotheliocytes, fibroblasts and adventitial cells was increased, showing a significant stimulation of their DNA-synthesizing capacity. The histological findings obtained indicate that the introduction of oxytocin in complex treatment activates the processes of vasculogenesis, proliferation of endotheliocytes anf histiocytes, that, in turn, results in the effective clearance of the wound and optimal granulation tissue formation.

[Correction of hyperglycemia in diabetic patients with postinjection abscesses]. / Korrektsiia giperglikemii u bol'nykh sakharnym diabetom i postin"ektsionnymi abstsessami.

Local use of oxytocin-antibacterial complexes in combination with treatment of diabetes including divided insulinotherapy in patients with postinjection abscesses and non-insulin-dependent diabetes led to compensation of diabetes and earlier sanation of suppurative focus compared with patients treated by local antibiotics only.

[Microbiological specifics in the course of suppurative inflammatory processes in soft tissues of patients with diabetes mellitus]. / Mikrobiologicheskie osobennosti techeniia gnoino-vospalitel'nykh protsessov miagkikh tkanei u bol'nykh sakharnym diabetom.

The focal microflora of pyo-inflammatory processes has been studied in dynamics in 200 patients with diabetes mellitus. It was found that a longer and more severe course was due to the changed specific composition of causative agents and to the increased specific diversity of the latter in the process of pyo-inflammatory progressing. It was established that the usage of the method of "close" wound management with the application of oxytocin inhibited the change of the causative agents in the course of the disease, led to a more rapid elimination of microorganisms from the pyo-inflammatory focus, to the less frequency of recurrent surgical interventions and shorter duration of courses of treatment in contrast to the results obtained with the other methods of treatment.

[The use of oxytocin in the combined treatment of suppurative-necrotic lesions of the feet in diabetic patients]. / Primenenie oksitotsina v kompleksnom lechenii pri gnoino-nekroticheskikh porazheniiakh stop u bol'nykh s sakharnym diabetom.

The results of treatment of 90 patients with diabetes mellitus and pyo-necrotic lesions of the feet were compared. Oxytocin was used in 40 of the patients. It was found that parenteral administration of oxytocin resulted in more favorable course of diabetes mellitus in such patients. The intra-arterial or local use of Oxytocin was found to reliably increase the DNA synthesis by the endothelial cells, fibroblasts and histiocytes, which in its turn creates favorable conditions for the reparative process in the wounds and allows quality of the treatment to be considerably improved.