Family Resilience during COVID-19 Pandemic: A Literature Review.

Introduction: The COVID-19 pandemic has spread rapidly in many countries. This pandemic has led to short-term as well as long-term psychosocial and mental health implications for all family members. The magnitude of family resilience is determined by many vulnerability factors like developmental age, educational status, preexisting mental health condition, being economically underprivileged or being quarantined due to infection or fear of infection. Methods: PubMed, SCOPUS, MEDLINE, Google Scholar, Cochrane, and ProQuest were searched from the inception of the pandemic to December 31, 2020. Articles were screened for inclusion by Authors. Results: After exclusion, there were eight studies included in the analysis with 165,515 participants. The literature review demonstrated that pandemic has caused mental health problems such as anxiety, stress, and depression. Creating daily practices of gratitude is important to build family wellbeing. It is essential to have good and healthy communication and to find positive activities to do together among family members which can build a sense of togetherness, trust, cohesion, and happiness. Conclusion: In conclusion, the pandemic has caused unpredictable and uncertain impacts that can pose a threat to the wellbeing of the families. Pandemic has caused mental health problems such as anxiety, stress, and depression. A healthy relationship, communication, faith-based practices, a positive mindset, and building social support are adaptive coping to respond to the crisis and adversity together.

Pregnancy resumption following contraceptive discontinuation: Hazard survival analysis of the Indonesia Demographic and Health Survey Data 2007, 2012 and 2017.

OBJECTIVE: The objective of this research is to estimate the probability of pregnancy resumption after discontinuing reversible contraceptives-pills, injectables, implants and IUDs, and to examine the factors associated with the resumption of fertility. METHOD: The study uses pregnancy calendar data from Indonesia Demographic and Health Surveys (IDHS) of 2007, 2012 and 2017. A hazard model survival method is used for estimating the time needed to resume pregnancy since discontinuing reversible contraceptives. Retrospective data on 4,573; 5,183 and 5,989 episodes of reversible contraceptive discontinuation at the three surveys respectively have been analysed. RESULTS: This study shows that women regained fecundity within one year of discontinuing IUD, pill, injectables or implants. Women using IUD could resume their pregnancy faster than those using implants, pills and injectables. Over the three IDHS 2007, 2012 and 2017 the age-specific percentages of women becoming pregnant after one year of contraceptive discontinuation vary between 72 and 85 for IUD, 75 and 81 for pills, 72 and 76 for implants and 64 and 67 for injectables, with the percentages being higher among younger women. The analysis further shows that length of contraceptive use, parity, prior sexually transmitted infections, knowledge of fertile period, household wealth status and place of residence have no impact on occurrence of pregnancy after contraceptive discontinuation. CONCLUSION: The analysis disproves a myth that reversible contraceptives make women infertile. Depending on the type of reversible contraceptive used, 65% to 85% of the women were able to conceive after one year of discontinuation.

In vivo assessment of OXPHOS capacity using 3 T CrCEST MRI in Friedreich's ataxia.

BACKGROUND: Friedreich's ataxia (FRDA) is a neurodegenerative disease caused by decreased expression of frataxin, a protein involved in many cellular metabolic processes, including mitochondrial oxidative phosphorylation (OXPHOS). Our objective was to assess skeletal muscle oxidative metabolism in vivo in adults with FRDA as compared to adults without FRDA using chemical exchange saturation transfer (CrCEST) MRI, which measures free creatine (Cr) over time following an in-magnet plantar flexion exercise. METHODS: Participants included adults with FRDA (n = 11) and healthy adults (n = 25). All underwent 3-Tesla CrCEST MRI of the calf before and after in-scanner plantar flexion exercise. Participants also underwent whole-body dual-energy X-ray absorptiometry (DXA) scans to measure body composition and completed questionnaires to assess physical activity. RESULTS: We found prolonged post-exercise exponential decline in CrCEST (τCr) in the lateral gastrocnemius (LG, 274 s vs. 138 s, p = 0.01) in adults with FRDA (vs. healthy adults), likely reflecting decreased OXPHOS capacity. Adults with FRDA (vs. healthy adults) also engaged different muscle groups during exercise, as indicated by muscle group-specific changes in creatine with exercise (∆CrCEST), possibly reflecting decreased coordination. Across all participants, increased adiposity and decreased usual physical activity were associated with smaller ∆CrCEST. CONCLUSION: In FRDA, CrCEST MRI may be a useful biomarker of muscle-group-specific decline in OXPHOS capacity that can be leveraged to track within-participant changes over time. Appropriate participant selection and further optimization of the exercise stimulus will enhance the utility of this technique.

The use of long-acting and permanent contraceptive methods (LAPMs) among women who have completed childbearing in Indonesia: does informed choice matter?

OBJECTIVES: This study examined factors associated with long-acting and permanent contraceptive methods use among married women who completed childbearing in Indonesia. METHODS: Data were extracted from the 2017 Indonesia Demographic and Health survey. Subjects of this study comprised 12,790 (weighted) married women aged 15-49 years who completed their childbearing and used modern contraceptive methods. Logistic regression adjusted for complex sample was used to assess factors associated with LAPMs use among women in Indonesia. RESULTS: Only 28% of the participants used long-acting and permanent contraceptive methods. Older women, higher number of living children, higher educational level, informed choice, and living in urban areas were associated with higher likelihood of adopting long-acting and permanent contraceptive methods. Women who received comprehensive counselling on contraceptive methods were more likely to adopt long-acting and permanent contraceptive methods compared with women who did not receive comprehensive counselling on contraceptive methods (AOR = 1.23; 95% CI: 1.07-1.41). Women who attained secondary (AOR = 1.31; 95% CI: 1.14-1.50) or higher (AOR = 2.36; 95% CI: 1.91-2.91) educational level were more likely to use long-acting and permanent contraceptive methods compared to women with primary education or less. The use of long-acting and permanent contraceptive methods was higher among women aged 35-49 (AOR = 1.41; 95% CI: 1.24-1.61) and women who have three or more living children (AOR = 1.75; 95% CI: 1.57-1.96) than their counterparts. CONCLUSION: The use of long-acting and permanent contraceptive methods was still low, even though there were more than half of women completed childbearing. The informed choice had a key role in improving long-acting and permanent contraceptive methods uptake. Training programs on contraceptive counselling for health providers and improving couple's awareness on the effectiveness of long-acting and permanent contraceptive methods were suggested to increase long-acting and permanent contraceptive methods adoption.

Exclusive Breastfeeding Practice in Indonesia: A Population-Based Study.

BACKGROUND: It is a well-known fact that exclusive breastfeeding benefits both mothers and their babies. The aim of this study is to assess the associated factors influencing exclusive breastfeeding of babies until 6 months of age. METHODS: The study used data from the 2017 Indonesia Demographic and Health Survey. Overall, 1,542 women who had infants aged below 6 months were included in the study. Sociodemographic and maternal health service utilization factors were examined for association with exclusive breastfeeding, using logistic regression for a complex sample design. RESULTS: The proportion of exclusive breastfeeding was 52.3% (95% confidence interval [CI], 0.498-0.548). Parity, antenatal care visits, early initiation of breastfeeding, low-income households, and rural areas were significant factors associated with the increased likelihood of exclusive breastfeeding. However, working status (adjusted odds ratio [aOR], 0.70; 95% CI, 0.57-0.86) and caesarean delivery or C-section (aOR, 0.75; 95% CI, 0.57-0.99) were factors for a lower likelihood of exclusive breastfeeding. CONCLUSION: Working women are at risk of discontinuation of exclusive breastfeeding. Mothers who had a normal vaginal delivery and practiced early initiation of breastfeeding had a higher rate of exclusive breastfeeding. These findings have important implications for developing comprehensive guidance and resources for women regarding the importance of exclusive breastfeeding during the early postpartum period.

The vulnerability of rural elderly Indonesian people to disability: an analysis of the national socioeconomic survey.

INTRODUCTION: There is a high prevalence of elderly people aged 65 years and older with disabilities in low- and middle-income countries, including Indonesia. This study examined urban-rural disparities in disabilities among elderly Indonesian people by adopting the International Classification of Functioning, Disability and Health scheme. METHODS: The cross-sectional design used a sample of 16 054 people aged 65 years and over from the 2018 National Socio-Culture and Education Module of the National Socio-Economic Survey (Susenas-MSBP). Disability was measured by functional status questionnaires of Susenas that had adopted the UN Washington Group's short set of disability questions. The threshold was at least one of the six domains coded 'a lot of difficulty' or 'can't do it all', or two of the six domains coded 'some difficulty'. Logistic regression analysis was performed to examine disability-associated factors. RESULTS: The prevalence of disability in this study was 35.1%. Among adults aged ≥65 years, those aged ≥85 years had the highest odds of having a disability (odds ratio (OR) 4.57, 95% confidence interval (CI) 4.54-4.59). Unemployed elderly people had a higher risk of disability than employed elderly people (OR 2.48, 95%CI 2.47-2.49). Elderly people who did not participate in leisure activities were 1.8 times more likely to have a disability than those who participated in leisure activities. Elderly people were more vulnerable to disabilities if they were female, unmarried, had a low balanced protein intake, and had health conditions. Physical exercise was a protecting factor against disability among elderly people. Compared with the results for elderly urban people, percentages for high educational attainment, high balanced protein intake, and leisure activities were lower for elderly rural people. CONCLUSION: Elderly rural people in Indonesia were more vulnerable to disabilities than elderly urban people were, which could be attributed to lower educational attainment, a lower balanced protein intake, and fewer leisure activities. As a result, the importance of socializing with family or friends, a high balanced protein intake, and leisure activities in assisting elderly rural people with disability issues must be emphasized.

Multimodality assessment of heart failure with preserved ejection fraction skeletal muscle reveals differences in the machinery of energy fuel metabolism.

AIMS: Skeletal muscle (SkM) abnormalities may impact exercise capacity in patients with heart failure with preserved ejection fraction (HFpEF). We sought to quantify differences in SkM oxidative phosphorylation capacity (OxPhos), fibre composition, and the SkM proteome between HFpEF, hypertensive (HTN), and healthy participants. METHODS AND RESULTS: Fifty-nine subjects (20 healthy, 19 HTN, and 20 HFpEF) performed a maximal-effort cardiopulmonary exercise test to define peak oxygen consumption (VO2, peak ), ventilatory threshold (VT), and VO2 efficiency (ratio of total work performed to O2 consumed). SkM OxPhos was assessed using Creatine Chemical-Exchange Saturation Transfer (CrCEST, n = 51), which quantifies unphosphorylated Cr, before and after plantar flexion exercise. The half-time of Cr recovery (t1/2, Cr ) was taken as a metric of in vivo SkM OxPhos. In a subset of subjects (healthy = 13, HTN = 9, and HFpEF = 12), percutaneous biopsy of the vastus lateralis was performed for myofibre typing, mitochondrial morphology, and proteomic and phosphoproteomic analysis. HFpEF subjects demonstrated lower VO2,peak , VT, and VO2 efficiency than either control group (all P < 0.05). The t1/2, Cr was significantly longer in HFpEF (P = 0.005), indicative of impaired SkM OxPhos, and correlated with cycle ergometry exercise parameters. HFpEF SkM contained fewer Type I myofibres (P = 0.003). Proteomic analyses demonstrated (a) reduced levels of proteins related to OxPhos that correlated with exercise capacity and (b) reduced ERK signalling in HFpEF. CONCLUSIONS: Heart failure with preserved ejection fraction patients demonstrate impaired functional capacity and SkM OxPhos. Reductions in the proportions of Type I myofibres, proteins required for OxPhos, and altered phosphorylation signalling in the SkM may contribute to exercise intolerance in HFpEF.

Predictors of early initiation of breastfeeding in Indonesia: A population-based cross-sectional survey.

INTRODUCTION: Commencing breastfeeding within one hour of birth is defined as early initiation of breastfeeding (EIBF). Both the mother and child benefit from EIBF. This study aims to identify the predictors of EIBF among Indonesian women. METHODS: This paper analyses data from a weighted sample of 6,616 women collected at the Indonesia Demographic and Health Survey (IDHS) 2017.The frequency of EIBF is measured by the proportion of children born in the two years preceding the survey who received breastmilk within one hour of birth. The analysis uses bivariate and multivariate logistic regression for complex sample designs, adjusted for confounders to examine the relationship of EIBF with women's individual, household and community level characteristics. RESULTS: Overall, 57% (95% CI: 54.9%-58.2%) of the children born in the two years preceding the survey had EIBF. Statistically significant (p<0.05) predictors of EIBF are women's non-working status, second or higher order of the birth of the most recent child, average or large size of the most recent child at birth, poor status of the household and non-agricultural work of the woman's husband; while statistically highly significant (p<0.01) predictors are skin-to-skin contact with the new-born (OR: 2.62; 95% CI: 2.28-3.00), Caesarean deliveries (OR: 0.47; 95% CI: 0.40-0.56), and skilled birth attendants (OR: 1.83; 95% CI: 1.65-2.08). Caesarean deliveries reduce the likelihood of EIBF by half compared to vaginal deliveries. Women's age, education or rural-urban residence display no statistically significant relationship with EIBF. CONCLUSION: Skin-to-skin contact, mode of delivery and type of birth attendance exert the strongest influence on EIBF in Indonesia in 2017. EIBF should be continuously promoted and supported particularly among mothers who do not have early skin-to-skin contact with their new-born, who have Caesarean deliveries and who have no skilled birth attendant.