RESUMO
We developed an efficient and straightforward I2-catalyzed strategy for the synthesis of functionalized α-amidohydroxyketones and symmetrical and unsymmetrical bisamides using incipient benzimidate scaffolds as starting materials and moist-DMSO as a reagent and solvent. The developed method proceeds through chemoselective intermolecular N-C-bond formation of benzimidates and the α-C(sp3)-H bond of acetophenone moieties. The key advantages of these design approaches include broad substrate scope and moderate yields. High-resolution mass spectrometry of the reaction progress and labeling experiments provided suitable evidence regarding the possible mechanism. 1H nuclear magnetic resonance titration revealed notable interaction between the synthesized α-amidohydroxyketones and some anions as well as biologically important molecules, which revealed a promising recognition property of these valuable motifs.
RESUMO
We discover an important property of a small molecule ArCH(OMe)2 which transforms catalytically inactive Pt(II)Br2 procatalyst in situ to an powerful catalyst Pt(IV)-species for diverse annulation reaction. The powerful catalytic system enables selective activation of C2-H/N-H and C2-H/C4-H of acetoacetanilide and C=O/C≡C of substituted butyne-1,2-dione for C-C/C-N, C-C/C-C and C-O/C-O bond-forming inter- and intramolecular annulation towards direct syntheses of functionalised 2-pyridones, cyclohexenones and 3(2H)-furanones respectively. In contrast to the common ligand, herein highly labile C-OMe bond of ArCH(OMe)2 is expected to react with PtBr2 towards generation of the high-valent active catalyst. Unlike catalyst promoter or initiator, the reaction does not occur with PtBr2 in the absence of ArCH(OMe)2. In situ generation of Pt(IV)-species and -OMe fragment of ArCH(OMe)2 were confirmed from the UV-vis characteristic peaks about 260â nm and trapping of -OMe group respectively. These observations provide new prospects and perspectives in catalysis for innovative catalyst design.
RESUMO
CeCl(3)·7H(2)O is found as an efficient catalyst for new intermolecular domino reactions of three-, four- and seven-component assemblies of common precursors under benign reaction conditions. Generation of enaminioesters from ß-keto esters and primary amines, activation of their allylic sp(3) C-H, vinylic sp(2) C-H and N-H bonds, multi C-C and C-N bond-forming cascade cyclization with 1,2-diketones and subsequent side-chain alkylation have been developed to construct functionalized pentasubstituted pyrroles and their chiral analogues. The scope of the domino reaction is successfully explored toward synthesis of highly aryl-substituted pyrroles, pentasubstituted pyrroles bearing C2-olefinic side-chain and spiro-2-pyrrolinones and their chiral analogues via unusual side-chain amination, elimination and ring contraction. The new domino reaction is operationally simple, robust, substrate specific, selective and high yielding.
Assuntos
Cério/química , Pirróis/química , Pirróis/síntese química , Catálise , Ciclização , Estrutura MolecularRESUMO
A cascade cyclization involving union of three imines by an organocatalyst proline is established to afford new fused-tetrahydroimidazo[1,5-c]imidazol-7-ones with excellent regio- and stereoselectivity. Another dehydrogenative cyclization by union of two imines is developed using the Cu(OTf)(2)-Ag(2)O combo catalyst to furnish functionalized imidazoles.
Assuntos
Imidazóis/síntese química , Iminas/química , Catálise , Ciclização , Imidazóis/química , Modelos Moleculares , Prolina/química , EstereoisomerismoRESUMO
The first ever breakthrough toward activation of ß-ketoacetanilide and subsequent C-C and C-N bond-forming intermolecular-cascade cyclization processes is demonstrated by development of the unprecedented Lewis acid property of non-toxic FeCl(3)â 6H(2)O. Aromatic, aliphatic, α,ß-unsaturated, chiral sugar-based and chromone aldehydes were regio- and stereoselectively cyclized with acetoacetanilides toward construction of valuable N-containing highly functionalized 2-pyridones (see scheme for an example).
Assuntos
Acetanilidas/química , Aldeídos/química , Cloretos/química , Compostos Férricos/química , Piridonas/síntese química , Catálise , Ciclização , Estrutura Molecular , Piridonas/química , EstereoisomerismoRESUMO
Activation of π-bond with organic Lewis acid and cationic surfactant mediated direct transfer of halides to alkyne and alkene are demonstrated to afford α,α-dihaloketones and other valuable synthons with outstanding selectivities.