A case of neoadjuvant chemotherapy in pregnancy with cervical cancer (IB3).

Compared with the early symptoms of non-pregnancy, the early pregnancy with cervical cancer is often confused with threatened abortion, so it is difficult to diagnose and delay the time of treatment. At present, compared with cervical cancer, there is no clear and standard treatment for cervical cancer in pregnancy. At present, the diagnosis and treatment plan is mainly made according to the pathological examination, staging, fetal development (whether there is abnormality on ultrasound and whether the chromosome karyotype is normal or not) and the pregnant women and their family members' pregnancy wishes. A case of pregnancy complicated with cervical cancer who was terminated by planned cesarean section after neoadjuvant chemotherapy (NACT) with irregular vaginal bleeding as the first symptom was analyzed retrospectively.

Fabrication of a 2D metal-organic framework (MOF) nanosheet colloidal system and investigation of its fluorescence response to pesticide molecules.

Pesticides, as a type of toxic chemicals widely used for a long time, not only pollute the environment but also affect people's health and cause serious harm to the human body, soil and environment. Therefore, it is very necessary to exploit a portable and environmentally friendly method to detect pesticides with high sensitivity. Herein, a new luminescent metal-organic framework ([Zn(TPYBDC)·H2O]n, TPYBDC2- = 4'-(pyridin-4-yl)-[2,2':6',2''-terpyridine]-4,4''-dicarboxylate) with 2D coordination layers has been designed and assembled using 4'-(pyridin-4-yl)-[2,2':6',2''-terpyridine]-4,4''-dicarboxylic acid as the ligand. The as-synthesized Zn-LMOF was exfoliated to ultrathin 2D nanosheets (4-5 nm) to form a luminescence colloidal sensor by destroying the weak interaction between the coordination layers such as H-bonding between the matrix H2O and the coordination carboxyl oxygen, and the π-π interactions among the interlayer conjugated aromatic rings. Investigation of its recognition and detection ability towards chemical pesticides shows that it can sensitively detect pesticides such as imidacloprid, nitenpyram and dinotefuran via fluorescence quenching effect with very low detection limit (LOD). Using imidacloprid as a typical case, a LOD value of 0.562 µM and recoveries for the simulated agricultural environmental samples in the range of 94-115% suggests that the as-fabricated 2D Zn-MOF nanosheet colloidal sensor (Zn-LMOF probe) is a most promising candidate for sensing chemical pesticides.