RESUMO
In this study lymphapheresis over a 5-week period was compared with a period of rest in 8 patients with active severe rheumatoid arthritis. These patients failed to respond to gold or/and to D-penicillamine. All the patients treated by lymphapheresis improved in the first 2 or 3 weeks and one patient in the control group improved in 3 weeks. The laboratory findings and the 99mTc-pertechnetate uptake index of the joints were inconsistent. In this study lymphapheresis had a clinically modest beneficial effect which in 3 of 4 patients persisted even after 18 weeks.
Assuntos
Artrite Reumatoide/terapia , Leucaférese , Descanso , Artrite Reumatoide/diagnóstico , Estudos de Avaliação como Assunto , Feminino , Humanos , LinfócitosRESUMO
The effects of radiosynoviorthesis on chronic haemophilic arthropathic joints were studied in six patients with severe haemophilia by a follow up study which spanned two and a half years. On clinical grounds the treatment was successful because pain and bleeding frequency diminished, although radiographic examination showed further deterioration of the treated joint. Chromosome damage was not detected. We conclude that radiosynoviorthesis is apparently changing the bleeding pattern of articular tissues without arresting the destruction and deformation of joints.
Assuntos
Ouro Coloide Radioativo/uso terapêutico , Hemartrose/radioterapia , Adulto , Analgesia , Fator IX/uso terapêutico , Fator VIII/uso terapêutico , Humanos , MasculinoRESUMO
In order to evaluate the incidence and aetiology of hypergastrinaemia 53 patients with seropositive rheumatoid arthritis were examined for gastric acid secretion, fasting serum gastrin concentration, circulating parietal cell antibodies, and some parameters of the activity of inflammation of rheumatoid arthritis. The basal and maximum acid output was found to be subnormal in this group (P less than 0.01), and in 11 of these patients (23%) the fasting serum gastrin levels were raised (P less than 0.05). This hypergastrinaemia correlated strongly with maximum acid output. Only in cases of achlorhydria or hypochlorhydria (maximum acid output less than 2 mmol/l) was the serum gastrin level markedly raised. Two out of 5 patients with achlorhydria were found to have circulating parietal cell antibodies, and 1 had decreased absorption of vitamin B12. No relationship was found between serum gastrin and duration or activity of rheumatoid arthritis; nor was there a relationship between basal serum gastrin and the various antirheumatic drugs administered.
