1.
J Org Chem
; 74(16): 6365-7, 2009 Aug 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19606814
RESUMO
An efficient and metal-free protocol for direct oxidation of secondary amines to nitrones has been developed, using Oxone in a biphasic basic medium as the sole oxidant. The method is general and tolerant with other functional groups or existing stereogenic centers, providing rapid access to enantiomerically pure compounds in good yields.