RESUMO
Neutrophilic diseases may have various clinical presentations but share common histopathological manifestations with an aseptic infiltrate of polymorphonuclears neutrophils. The association with various diseases is frequent and must be systematically discussed. We report a patient who presented three different synchronous clinical manifestations of neutrophilic disease: pyoderma gangrenosum, subcorneal pustular dermatosis and aseptic spleen abscesses.
Assuntos
Abscesso/etiologia , Neutrófilos , Pioderma Gangrenoso/etiologia , Dermatopatias Vesiculobolhosas/etiologia , Esplenopatias/etiologia , Idoso de 80 Anos ou mais , Humanos , Masculino , Pioderma Gangrenoso/complicações , Dermatopatias Vesiculobolhosas/complicações , Esplenopatias/complicaçõesRESUMO
Chronic cavitary pulmonary aspergillosis requires a first-line prolonged treatment with itraconazole or voriconazole. We report a 71-year-old immunocompetent man with polyarteritis and history of multiple lung surgery procedures, who developed a peripheral axonal neuropathy 1 month after voriconazole therapy was started for a chronic cavitary pulmonary aspergillosis. After discontinuation of the treatment and a switch to posaconazole, the neuropathy partly improved. Three other cases of peripheral neuropathy with voriconazole have been already published, all reversible after voriconazole discontinuation.
Assuntos
Antifúngicos/efeitos adversos , Aspergilose Broncopulmonar Alérgica/tratamento farmacológico , Doenças do Sistema Nervoso Periférico/induzido quimicamente , Pirimidinas/efeitos adversos , Triazóis/efeitos adversos , Triazóis/uso terapêutico , Idoso , Antifúngicos/uso terapêutico , Doença Crônica , Humanos , Masculino , Dor/induzido quimicamente , Dor/fisiopatologia , Doenças do Sistema Nervoso Periférico/fisiopatologia , Pirimidinas/uso terapêutico , Resultado do Tratamento , VoriconazolRESUMO
Panton-Valentine leukocidin-producing (PVL) Staphylococcus aureus is responsible for a highly lethal necrotizing pneumonia, which occurs predominantly in young immunocompetent patients. Hemoptysis and leucopenia often occur but are not always present. Detection of PVL gene on S. aureus strains responsible for pneumonia should help us to a better understanding of this disease, to improve its treatment with antibiotics capable of lower the toxin production and to prevent its diffusion to others persons by detection and elimination of a nasal S. aureus carriage.
