RESUMO
A study was undertaken to weigh the effects of air pollution and oxygen at high pressure on the susceptibility of mice to Coxsackievirus B1 infection. Animals exposed to air pollutants or oxygen at high pressure were found to contain higher amounts of recoverable virus than control animals. Animals exposed to both air pollutants and oxygen at high pressure were found to contain the greatest levels of recoverable virus. This same group of animals was also found to have hearts which were smaller than any other group. Animals maintained in an ambient atmosphere had higher levels of recoverable virus and smaller hearts than animals exposed to terpene vapors and hyperbaric oxygen. The results of this study suggest that terpene vapors may nullify the activity of oxygen at high pressure.
Assuntos
Poluentes Atmosféricos/toxicidade , Enterovirus/efeitos dos fármacos , Oxigenoterapia Hiperbárica , Terpenos/toxicidade , Replicação Viral/efeitos dos fármacos , Animais , Enterovirus/isolamento & purificação , Feminino , Coração/anatomia & histologia , Coração/microbiologia , Camundongos , Camundongos Endogâmicos , Tamanho do Órgão , GravidezRESUMO
Periodic comparisons were made of sera from two groups of patients, ten who rejected their renal transplants within a year after transplantation and ten who successfully maintained their transplanted kidneys for five years or more. What appeared to be anti-kidney cytotoxic antibodies were found in much higher levels in the sera of those patients with the short-lived transplants, the difference in titer levels between the two groups being significant at the .0001 levels. This antibody showed no correlation with either the presence or the absence of lymphocytotoxic antibodies, nor did it appear to have any relationship to the HL-A antigens or the previous renal disease of the recipient patient. While it was cytotoxic to tissue cultures of cells obtained from random human kidneys, human kidney tumor cells (Wilms), and human embryonic kidneys, this antibody did not react with non-renal human tissues (lung, spleen, deltoid muscle, foreskin). It did not react with nonhuman (simian) kidney tissue culture cells. The findings suggest the appearance of an organ-specific, cytotoxic anti-kidney antibody in patients undergoing renal homograft rejection.
