RESUMO
Students' and graduates' mobility is an interesting topic of discussion especially for the Italian education system and universities. The main reasons for migration and for the so called brain drain, can be found in the socio-economic context and in the famous North-South divide. Measuring mobility and understanding its dynamic over time and space are not trivial tasks. Most of the studies in the related literature focus on the determinants of such phenomenon, in this paper, instead, combining tools coming from graph theory and Topological Data Analysis we propose a new measure for the attitude to mobility. Each mobility trajectory is represented by a graph and the importance of the features constituting the graph are evaluated over time using persistence diagrams. The attitude to mobility of the students is then ranked computing the distance between the individual persistence diagram and the theoretical persistence diagram of the stayer student. The new approach is used for evaluating the mobility of the students that in 2008 enrolled in an Italian university. The relation between attitude to mobility and the main socio-demographic variables is investigated.
RESUMO
BACKGROUNDS: Validated tools for predicting individual in-hospital mortality of COVID-19 are lacking. We aimed to develop and to validate a simple clinical prediction rule for early identification of in-hospital mortality of patients with COVID-19. METHODS AND FINDINGS: We enrolled 2191 consecutive hospitalized patients with COVID-19 from three Italian dedicated units (derivation cohort: 1810 consecutive patients from Bergamo and Pavia units; validation cohort: 381 consecutive patients from Rome unit). The outcome was in-hospital mortality. Fine and Gray competing risks multivariate model (with discharge as a competing event) was used to develop a prediction rule for in-hospital mortality. Discrimination and calibration were assessed by the area under the receiver operating characteristic curve (AUC) and by Brier score in both the derivation and validation cohorts. Seven variables were independent risk factors for in-hospital mortality: age (Hazard Ratio [HR] 1.08, 95% Confidence Interval [CI] 1.07-1.09), male sex (HR 1.62, 95%CI 1.30-2.00), duration of symptoms before hospital admission <10 days (HR 1.72, 95%CI 1.39-2.12), diabetes (HR 1.21, 95%CI 1.02-1.45), coronary heart disease (HR 1.40 95% CI 1.09-1.80), chronic liver disease (HR 1.78, 95%CI 1.16-2.72), and lactate dehydrogenase levels at admission (HR 1.0003, 95%CI 1.0002-1.0005). The AUC was 0.822 (95%CI 0.722-0.922) in the derivation cohort and 0.820 (95%CI 0.724-0.920) in the validation cohort with good calibration. The prediction rule is freely available as a web-app (COVID-CALC: https://sites.google.com/community.unipa.it/covid-19riskpredictions/c19-rp). CONCLUSIONS: A validated simple clinical prediction rule can promptly and accurately assess the risk for in-hospital mortality, improving triage and the management of patients with COVID-19.
