1.
Ann Fr Anesth Reanim
; 30(11): 851-2, 2011 Nov.
Artigo
em Francês
| MEDLINE
| ID: mdl-22018791
Assuntos
Anestesia , Anestésicos Intravenosos , Endoscopia/métodos , Médicos , Propofol , Aprovação de Drogas , França , Guias como Assunto , Sociedades Médicas
2.
Life Sci
; 68(11): 1317-21, 2001 Feb 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11233998
RESUMO
The effect of resveratrol, an aryl hydrocarbon receptor (AhR) antagonist, known to inhibit inducible cyclooxygenase-2 (COX2) and its transcription were examined in a model of hyperalgesia induced by carrageenan in the rat. Pretreatment with resveratrol did not reverse swelling and edema, but reversed the hyperalgesia induced by local tissue injury provoked by carrageenan. This reversal, occurring at resveratrol concentrations as low as 2 mg/kg, lasted for at least 48 hours. The link with COX2 activity inhibition and COX2 gene transcription, as well as a potential AhR inhibitory effect, remain to be established.