1.
Biochem J
; 271(1): 269-72, 1990 Oct 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-2222418
RESUMO
Using the laser dye rhodamine 123, we demonstrated that local anaesthetics can reach mitochondria in cell culture and reversibly decrease, or even collapse, their transmembrane potential. This effect is highly dependent on the lipid-solubility of the local anaesthetic and can be facilitated by the presence of a lipophilic anion.