Expanded postexposure prophylaxis for simultaneous multiple source HIV exposure in a health-care worker.

We report an extreme case of high-grade needlestick exposure of a health-care worker to serum from multiple HIV-infected patients after trying to prematurely remove the respective tubes from an automated biochemical analyser. After review of the medical records of the eight source patients, we offered the health-care worker an expanded postexposure prophylaxis regimen including the entry inhibitor enfuvirtide. She refused to take subcutaneous injections, so we recommended the use of the integrase inhibitor raltegravir. She completed therapy without problems and periodic evaluation for HIV transmission up to nine months after the incident was negative.

Solid variant of primary effusion lymphoma in successfully treated HIV infection: a case report.

Primary effusion lymphoma (PEL) is a unique form of non-Hodgkin lymphoma, mainly met in severely immunocompromised, HIV-positive patients. PEL is aetiologically related to human herpes virus-8 (HHV-8) and it usually presents as a lymphomatous body cavity effusion in the absence of a solid tumour mass. Recently, cases of HIV-positive patients with HHV-8-positive solid tissue lymphomas, not associated with an effusion, have been reported (solid variant of PEL). The prognosis of PEL is reported to be poor. We report a case of an HIV-positive patient with a typical solid variant of PEL without effusion. Interestingly, his disease developed while being on stable antiretroviral therapy (ART) with high CD4 counts. He had a relatively long survival with chemotherapy and ART.

Improved flower advertisement, pollinator rewards and seed yield by enhanced UV-B radiation in the Mediterranean annual Malcolmia maritima.

• The effects of enhanced UV-B radiation on reproductive and pollination success were investigated in the Mediterranean annual Malcolmia maritima. • Plants were exposed in the field to ambient or ambient plus supplemental UV-B radiation (biologically equivalent to a 15% ozone depletion over Patras, Greece, 38°14' N, 21°44' E) up to leaf senescence and fruit maturation. • UV-B radiation had no effect on stem and fruit biomass, anthesis time and duration and flower number. However, flower diameter, nectary volume and nectar amount per flower (but not nectar concentration) were significantly increased by supplemental UV-B radiation. In addition UV-B treated plants showed higher reproductive success (i.e. lower abortion rates and higher fruit to flower ratio) and a trend to higher pollination success (i.e. increased number of seeds per fruit). As a result, the seed yield was increased. Seed mass, seed germination and early seedling growth were not affected by UV-B treatment of mother plants. • It is suggested that the UV-B induced changes in flower attributes might have affected pollinators' behaviour in a way that improved the fitness of M. maritima.