[The results of the radiation treatment of cervical cancer using low, sensitizing doses of radiation]. / Rezul'taty luchevogo lecheniia raka sheiki matki s ispol'zovaniem malykh sensibiliziruiushchikh doz radiatsii.

Combined radiation treatment for cervical cancer is associated with radiation injury to the intestine, bladder, hemopoietic system and suppression of T-system, nonspecific immunity and thyroid function. Modified gamma-ray teletherapy was suggested which included low-dose (0.1 Gy) sensitizing irradiation of tumor and zones of regional dissemination prior to delivering therapeutic dose (1.9 Gy). The procedure assured lower incidence of radiation-induced reactions and complications, leukopenia and T-lymphocyte function suppression, stimulated nonspecific resistance and thyrotropic function of the pituitary, and provided normal function of the thyroid. As a result, five-year survival rate in patients with stage III cancer increased by 14%.

[Effect of sensitizing doses of radiation on hormonal homeostasis in combined radiation treatment of cervical cancer]. / Vliianie sensibiliziruiushchikh doz oblucheniia na gormonal'nyi gomeostaz pri sochetannom luchevom lechenii raka sheiki matki.

Low sensitizing doses given to patients with cervical carcinoma in the course of complex radiation treatment were responsible for a greater decrease in the frequency of radiation injuries to the intestine as compared with standard complex radiation procedure. This was matched by an increase in the incidence of exacerbation of chronic adnexitis. Radiation appeared to inhibit thyroid function. Low sensitizing dose treatment given in the course of complex radiotherapy did not affect the gland's function. However, cases of stage III cancer exhibited a more pronounced decrease in thyrotrophin levels accompanied by higher somatotropin levels.