1.
Chem Commun (Camb)
; 55(61): 8959-8962, 2019 Aug 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31290487
RESUMO
Hydrocarbon stapled peptides are promising therapeutics for inhibition of intracellular protein-protein interactions. Here we develop a new high-throughput strategy for hydrocarbon stapled peptide discovery based on mRNA display of peptides containing α-methyl cysteine and cyclized with m-dibromoxylene. We focus on development of a peptide binder to the HPV16 E2 protein.