RESUMO
It has been established that the development of acute pancreatitis is accompanied by the reduced activity of glutamate dehydrogenase in the mitochondrial fraction of pancreas, pronounced in the focus of tissue necrosis and less expressed in the reactive inflammation focus. Besides this in the pancreas redistribution of enzyme, activity in the subcellular organelles takes place and enzyme activity emerges in the cytosol and further--in the blood and peritoneum liquid. Sodium thiosulfate has a marked correlation effect.
Assuntos
Antídotos/farmacologia , Antioxidantes/farmacologia , Quelantes/farmacologia , Glutamato Desidrogenase/análise , Pâncreas/enzimologia , Pancreatite/enzimologia , Tiossulfatos/farmacologia , Doença Aguda , Animais , Mitocôndrias/enzimologia , Organelas/enzimologia , Pâncreas/efeitos dos fármacos , Pâncreas/ultraestrutura , RatosRESUMO
It has been experimentally and clinically established that the determination of leucine-aminotransferase activity in the blood serum and abdominal exudate may serve as a marker for the early determination of pancreonecrosis and edematous (serous) pancreatitis.