Effect of gluten free diet on gastrointestinal and behavioral indices for children with autism spectrum disorders: a randomized clinical trial.

BACKGROUND: Genetic and environmental factors are both responsible for the etiology of autism spectrum disorders (ASD). Although epidemiological studies have been conducted to clarify the association between restriction diets and ASD, the conclusion remains unclear. This study was undertaken to investigate the effect of gluten free diet (GFD) on gastrointestinal symptoms and behavioral indices in children with ASD. METHODS: In this randomized clinical trial, 80 children diagnosed with ASD by the Autism Diagnostic Interview-Revised (ADI-R) were assigned into GFD (n=40) and regular diet (RD) (n=40) groups for 6 weeks. At the beginning and end of the intervention, the ROME Ш questionnaire for evaluating gastrointestinal symptoms and Gilliam Autism Rating Scale 2 questionnaire (GARS-2) for assessing psychometric properties were completed. RESULTS: Of the 80 children, 53.9% had gastrointestinal abnormalities. In the GFD group, the prevalence of gastrointestinal symptoms decreased significantly (P<0.05) after intake of GFD (40.57% vs. 17.10%) but increased insignificantly in the RD group (42.45% vs. 44.05%). GFD intervention resulted in a significant decrease in behavioral disorders (80.03±14.07 vs. 75.82±15.37, P<0.05) but an insignificant increase in the RD group (79.92±15.49 vs. 80.92±16.24). CONCLUSION: This study suggested that GFD may be effective in controlling gastrointestinal symptoms and ASD behaviors.

Fluids Intake and Beverage Consumption Pattern among University Students.

BACKGROUND: Insufficient and inappropriate daily fluid intake in a long period may have adverse effect on human's health. Therefore, the present study evaluated the amounts and sources of fluids consumed by university students to determine whether these amounts and sources of fluid were enough and appropriate. METHODS: In this descriptive study, 245 (142 females and 103 males) volunteer students of Tabriz University of Medical Sciences in 2009 were recruited. Food and fluid intake of subjects were as-sessed by 24-hour recall method of 3 days (two week days and one week- end included). Dietary intake of subjects was analyzed by Nutritionist III software program. The mean total fluid intake (drinking fluid values merged with data on the water content of foods) and the rate of metabolic water were figured out. Comparisons of the results with recommended dietary values were made using student's t-test.. Data of dietary intakes for two under-reporter female subjects were not included in the statistical analysis. RESULTS: Daily total mean of fluid intake for girls (1598±40ml) and boys (1861±59ml) reflect the sum of beverages (Girls, 818±29ml; boys, 1147±57ml) and food water (Girls, 780±47ml; boys, 714±86m). The most consumed beverage for girls and boys were water (40%) and tea (49%) respectively. Daily mean intake of milk for girls and boys were 106.31±10ml (13%) and 57.30±11ml (5%), respectively. CONCLUSION: The mean daily fluid intake of subjects, specially water, and milk was lower than rec-ommended values. Therefore, there is an urgent need for tailored nutrition intervention targeting the young adults to improve their beverage choices.