Graphene Incorporated Electrospun Nanofiber for Electrochemical Sensing and Biomedical Applications: A Critical Review.

The extraordinary material graphene arrived in the fields of engineering and science to instigate a material revolution in 2004. Graphene has promptly risen as the super star due to its outstanding properties. Graphene is an allotrope of carbon and is made up of sp2-bonded carbon atoms placed in a two-dimensional honeycomb lattice. Graphite consists of stacked layers of graphene. Due to the distinctive structural features as well as excellent physico-chemical and electrical conductivity, graphene allows remarkable improvement in the performance of electrospun nanofibers (NFs), which results in the enhancement of promising applications in NF-based sensor and biomedical technologies. Electrospinning is an easy, economical, and versatile technology depending on electrostatic repulsion between the surface charges to generate fibers from the extensive list of polymeric and ceramic materials with diameters down to a few nanometers. NFs have emerged as important and attractive platform with outstanding properties for biosensing and biomedical applications, because of their excellent functional features, that include high porosity, high surface area to volume ratio, high catalytic and charge transfer, much better electrical conductivity, controllable nanofiber mat configuration, biocompatibility, and bioresorbability. The inclusion of graphene nanomaterials (GNMs) into NFs is highly desirable. Pre-processing techniques and post-processing techniques to incorporate GNMs into electrospun polymer NFs are precisely discussed. The accomplishment and the utilization of NFs containing GNMs in the electrochemical biosensing pathway for the detection of a broad range biological analytes are discussed. Graphene oxide (GO) has great importance and potential in the biomedical field and can imitate the composition of the extracellular matrix. The oxygen-rich GO is hydrophilic in nature and easily disperses in water, and assists in cell growth, drug delivery, and antimicrobial properties of electrospun nanofiber matrices. NFs containing GO for tissue engineering, drug and gene delivery, wound healing applications, and medical equipment are discussed. NFs containing GO have importance in biomedical applications, which include engineered cardiac patches, instrument coatings, and triboelectric nanogenerators (TENGs) for motion sensing applications. This review deals with graphene-based nanomaterials (GNMs) such as GO incorporated electrospun polymeric NFs for biosensing and biomedical applications, that can bridge the gap between the laboratory facility and industry.

Advanced Waveguide Based LOC Biosensors: A Minireview.

This mini review features contemporary advances in mid-infrared (MIR) thin-film waveguide technology and on-chip photonics, promoting high-performance biosensing platforms. Supported by recent developments in MIR thin-film waveguides, it is expected that label-free assimilated MIR sensing platforms will soon supplement the current sensing technologies for biomedical diagnostics. The state-of-the-art shows that various types of waveguide material can be utilized for waveguide spectroscopic measurements in MIR. However, there are challenges to integrating these waveguide platforms with microfluidic/Lab-on-a-Chip (LOC) devices, due to poor light-material interactions. Graphene and its analogs have found many applications in microfluidic-based LOC devices, to address to this issue. Graphene-based materials possess a high conductivity, a large surface-to-volume ratio, a smaller and tunable bandgap, and allow easier sample loading; which is essential for acquiring precise electrochemical information. This work discusses advanced waveguide materials, their advantages, and disease diagnostics with MIR thin-film based waveguides. The incorporation of graphene into waveguides improves the light-graphene interaction, and photonic devices greatly benefit from graphene's strong field-controlled optical response.

A user-friendly FIB lift-out technique to prepare plan-view TEM sample of 2D thin film materials.

Plan-view transmission electron microscopy (TEM) or electron diffraction imaging of a bulk or 2D material can provide detailed information about the structural or atomic arrangement in the material. A systematic and easily implementable approach to preparing site-specific plan-view TEM samples for 2D thin film materials using FIB is discussed that could be routinely used. The methodology has been successfully applied to prepare samples from 2D materials such as, MoS2 thin film, vertically oriented graphene film (VG), as well as heterostructure material SnTiS3. It is worth mentioning that in contrast to planar conventional graphene, VG grows vertically from the substrate and takes nanosheet arrays. Samples prepared using this methodology provide a simple, faster, and precise course in obtaining valuable structural information. The top-view imaging offers various information about the growth nature of the materials suggesting the efficiency of the sample preparation process.

Assessing the Stability of Inkjet-Printed Carbon Nanotube for Brine Sensing Applications.

In hostile environments, sensing is critical for many industries such as chemical and oil/gas. Within this industry, the deposition of scales or minerals on various infrastructure components (e.g., pipelines) forms a reliability hazard that needs to be monitored. Therefore, the approach adopted in this study to tackle this issue relies on the use of real-time sensing of specific ions in brine, the natural trigger for ions deposition. In order to do so, electrochemical sensors based on carbon nanotubes (CNTs) are developed, taking advantage of their unique properties facilitated by different synthesis and fabrication methods. One of these promising synthesis methods is inkjet printing of CNT films since in general, it has exceptional benefits over other approaches that are used to print CNTs. Furthermore, it does not need the use templates. In addition, it is a very fast technique with consistent printing results for many applications along with very low cost on various shapes/formfactors. As these sensors are exposed to a hostile environment (chemical, temperature, etc.), the stability of the CNT films is of great importance. In this study, a comprehensive investigation of the stability of CNT surfaces upon exposure to elements is presented. Accordingly, the several impacts of this interaction on physical properties of the surfaces as a function of interaction time and brine chemical composition are assessed. Moreover, the approach used for investigating the impact of this exposure involves the following: surface electrical resistance change using four probe measurements; surface roughness/topography using Atomic Force Microscopy (AFM) along Scanning Electron Microscopy (SEM); quality of CNT through Raman spectroscopy and wettability using the sessile drop method. The sensing capabilities of the devices are investigated by looking at the sensing selectivity of target ions, resetting capabilities, and sensing sensitivity manifested in the electrical resistance change. Consequently, our results indicate that while inkjet films are very promising sensor material, the fabrication and long term stability require further optimization of the films along with the process to make them meet reliability and lifetime requirements in the oil/gas hostile operational environments.

Divergent surface properties of multidimensional sp (2) carbon allotropes: the effect of aging phenomena.

Despite the current interest in the scientific community in exploiting divergent surface properties of graphitic carbon allotropes, conclusive differentiation remains elusive even when dealing with parameters as fundamental as adhesion. Here, we set out to provide conclusive experimental evidence on the time evolution of the surface properties of highly oriented pyrolytic graphite (HOPG), graphene monolayer (GML) and multiwalled carbon nanotubes (MWCNTs) as we expose these materials to airborne contaminants, by providing (1) statistically significant results based on large datasets consisting of thousands of force measurements, and (2) errors sufficiently self-consistent to treat the comparison between datasets in atomic force microscopy (AFM) measurements. We first consider HOPG as a model system and then employ our results to draw conclusions from the GML and MWCNT samples. We find that the surface properties of aged HOPG are indistinguishable from those of aged GML and MWCNT, while being distinct from those of cleaved HOPG. Herein, we provide a sufficient body of evidence to disregard any divergence in surface properties for multidimensional sp (2) carbon allotropes that undergo similar aging processes.

Microscopic droplet formation and energy transport analysis of condensation on scalable superhydrophobic nanostructured copper oxide surfaces.

Utilization of nanotechnologies in condensation has been recognized as one opportunity to improve the efficiency of large-scale thermal power and desalination systems. High-performance and stable dropwise condensation in widely-used copper heat exchangers is appealing for energy and water industries. In this work, a scalable and low-cost nanofabrication approach was developed to fabricate superhydrophobic copper oxide (CuO) nanoneedle surfaces to promote dropwise condensation and even jumping-droplet condensation. By conducting systematic surface characterization and in situ environmental scanning electron microscope (ESEM) condensation experiments, we were able to probe the microscopic formation physics of droplets on irregular nanostructured surfaces. At the early stages of condensation process, the interfacial surface tensions at the edge of CuO nanoneedles were found to influence both the local energy barriers for microdroplet growth and the advancing contact angles when droplets undergo depinning. Local surface roughness also has a significant impact on the volume of the condensate within the nanostructures and overall heat transfer from the vapor to substrate. Both our theoretical analysis and in situ ESEM experiments have revealed that the liquid condensate within the nanostructures determines the amount of the work of adhesion and kinetic energy associated with droplet coalescence and jumping. Local and global droplet growth models were also proposed to predict how the microdroplet morphology within nanostructures affects the heat transfer performance of early-stage condensation. Our quantitative analysis of microdroplet formation and growth within irregular nanostructures provides the insight to guide the anodization-based nanofabrication for enhancing dropwise and jumping-droplet condensation performance.