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1.
Z Naturforsch C J Biosci ; 79(3-4): 81-87, 2024 Mar 25.
Artigo em Inglês | MEDLINE | ID: mdl-38509702

RESUMO

Soft corals, particularly Sarcophyton sp. are rich in metabolites with variety of biological activities. In this study, a pyran-based 9-exo-methylene-10-hydroxy-sarcotrocheliol (1) and 2-dehydro-4-peroxy-sarcophine (2), two new cembranoide diterpenes, were isolated together with 9-hydroxy-10,11-dehydro-sarcotrocheliol, sarcotrocheliol, sarcotrocheliol acetate, sarcophine, (+)-7α,8ß-dihydroxydeepoxysarcophine, (±)-sarcophytonine B, and peridinin from the organic extract of Sarcophyton glaucum collected at the coasts of Hurghada, Egypt. The structures of the new diterpenes 1-2 were identified based on cumulative analyses of HRESIMS and NMR (1D/2D NMR) spectra. The relative configurations of both compounds were verified by NOESY spectra and comparison with our recently reported analogues. The compounds showed no antimicrobial activity against a set of diverse tested microorganisms.


Assuntos
Antozoários , Diterpenos , Diterpenos/química , Diterpenos/farmacologia , Diterpenos/isolamento & purificação , Antozoários/química , Animais , Espectroscopia de Ressonância Magnética , Testes de Sensibilidade Microbiana , Estrutura Molecular , Egito , Antibacterianos/farmacologia , Antibacterianos/química , Antibacterianos/isolamento & purificação
2.
Curr Probl Cardiol ; 46(3): 100484, 2021 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31610953

RESUMO

Spontaneous coronary artery dissection (SCAD) has emerged as an important cause of acute coronary syndrome and sudden cardiac death. The triggers for SCAD often do not include traditional atherosclerotic risk factors. The most commonly reported triggers are extreme physical or emotional stress. The current study compared in-hospital and follow-up events in patients with SCAD with and without reported stress. Data from 83 patients with a confirmed diagnosis of SCAD were collected retrospectively from 30 centers in 4 Arab Gulf countries (KSA, UAE, Kuwait, and Bahrain) from January 2011 to December 2017. In-hospital myocardial infarction (MI), percutaneous coronary intervention (PCI), ventricular tachycardia/ventricular fibrillation, cardiogenic shock, death, ICD placement, dissection extension) and follow-up (MI, de novo SCAD, death, spontaneous superior mesenteric artery dissection) events were compared between those with and without reported stress. Emotional and physical stress was defined as new or unusually intense stress, within 1 week of their initial hospitalization. The median age of patients in the study was 44 (37-55) years. Foty-two (51%) were women. Stress (emotional, physical, and combined) was reported in 49 (59%) of all patients. Sixty-two percent of women with SCAD reported stress, and 51 % of men with SCAD reported stress. Men more commonly reported physical and combined stress. Women more commonly reported emotional stress (P < 0.001). The presence or absence of reported stress did not impact on overall adverse cardiovascular events (P = 0.8). In-hospital and follow-up events were comparable in patients with SCAD in the presence or absence of reported stress as a trigger.


Assuntos
Anomalias dos Vasos Coronários , Intervenção Coronária Percutânea , Angústia Psicológica , Estresse Fisiológico , Doenças Vasculares , Árabes , Angiografia Coronária , Anomalias dos Vasos Coronários/etiologia , Anomalias dos Vasos Coronários/psicologia , Vasos Coronários , Dissecação , Humanos , Estudos Retrospectivos , Doenças Vasculares/etiologia , Doenças Vasculares/psicologia
3.
Curr Probl Cardiol ; 46(3): 100656, 2021 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-32839042

RESUMO

The COVID-19 pandemic had significant impact on health care worldwide which has led to a reduction in all elective admissions and management of patients through virtual care. The purpose of this study is to assess changes in STEMI volumes, door to reperfusion, and the time from the onset of symptoms until reperfusion therapy, and in-hospital events between the pre-COVID-19 (PC) and after COVID-19 (AC) period. All acute ST-segment elevation myocardial infarction (STEMI) cases were retrospectively identified from 16 centers in the Kingdom of Saudi Arabia during the COVID-19 period from January 01 to April 30, 2020. These cases were compared to a pre-COVID period from January 01 to April 30, 2018 and 2019. One thousand seven hundred and eighty-five patients with a mean age 56.3 (SD ± 12.4) years, 88.3% were male. During COVID-19 Pandemic the total STEMI volumes was reduced (28%, n = 500), STEMI volumes for those treated with reperfusion therapy was reduced too (27.6%, n= 450). Door to balloon time < 90 minutes was achieved in (73.1%, no = 307) during 2020. Timing from the onset of symptoms to the balloon of more than 12 hours was higher during 2020 comparing to pre-COVID 19 years (17.2% vs <3%, respectively). There were no differences between the AC and PC period with respect to in-hospital events and the length of hospital stay. There was a reduction in the STEMI volumes during 2020. Our data reflected the standard of care for STEMI patients continued during the COVID-19 pandemic while demonstrating patients delayed presenting to the hospital.


Assuntos
COVID-19 , Aceitação pelo Paciente de Cuidados de Saúde , Intervenção Coronária Percutânea , Infarto do Miocárdio com Supradesnível do Segmento ST , Tempo para o Tratamento/estatística & dados numéricos , COVID-19/epidemiologia , COVID-19/prevenção & controle , COVID-19/psicologia , Transmissão de Doença Infecciosa/prevenção & controle , Feminino , Humanos , Tempo de Internação/estatística & dados numéricos , Masculino , Pessoa de Meia-Idade , Avaliação de Processos e Resultados em Cuidados de Saúde , Aceitação pelo Paciente de Cuidados de Saúde/psicologia , Aceitação pelo Paciente de Cuidados de Saúde/estatística & dados numéricos , Intervenção Coronária Percutânea/métodos , Intervenção Coronária Percutânea/estatística & dados numéricos , Estudos Retrospectivos , SARS-CoV-2 , Infarto do Miocárdio com Supradesnível do Segmento ST/diagnóstico , Infarto do Miocárdio com Supradesnível do Segmento ST/epidemiologia , Infarto do Miocárdio com Supradesnível do Segmento ST/terapia , Arábia Saudita/epidemiologia , Índice de Gravidade de Doença , Padrão de Cuidado/organização & administração
4.
Nat Prod Res ; 33(20): 3029-3032, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-30600692

RESUMO

Herein, we report the isolation and stereo-structure of rare pyrane-based cembranoid diterpenes, 9-hydroxy-7,8-dehydro-sarcotrocheliol (1) and sarcotrocheliol (2), from Sarcophyton trocheliophorum collected from Red Sea. Absolute configurations of both compounds were revised based on single crystal X-ray analyses.


Assuntos
Antozoários/química , Diterpenos/química , Conformação Molecular , Animais , Cristalografia por Raios X , Oceano Índico , Estrutura Molecular
5.
Nat Prod Res ; 33(1): 24-33, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-29393673

RESUMO

During our continual searching programme for novel bioactive metabolites from Sarcophyton trocheliophorum, collected from Red Sea, we describe herein the isolation and structural elucidation of further two new pyrane-based cembranoid diterpenes: 9-hydroxy-7,8-dehydro-sarcotrocheliol (1) and 8,9-expoy-sarcotrocheliol acetate (2), along with the well-known sarcotrocheliol acetate (3), (+)-sarcophine (4), (+)-sarcophytoxide (5) and (-)-sarcophytoxide (6). The chemical structures of compounds 1 and 2 were determined on the basis of 1D and 2D NMR (1H, 13C, 1H-1H COSY, HMQC, HMBC and NOE), mass spectra (ESI and HR-ESIMS) and by comparison with related structures. The antimicrobial activities of the reported compounds 1-6 were investigated. According to the molecular docking study of compounds 1-6 using 3D structure of α,ß tubulin in complex with taxol (PDB code 1JFF) and epothilone A (PDB code 1TVK), sarcophine (4) displayed the highest affinity towards both crystal structures, followed by 5 and 6, meanwhile pyrane-based cembranoid diterpenes (1-3) showed less affinity.


Assuntos
Antozoários/química , Anti-Infecciosos/farmacologia , Diterpenos/isolamento & purificação , 4-Butirolactona/análogos & derivados , Animais , Anti-Infecciosos/isolamento & purificação , Epotilonas/metabolismo , Oceano Índico , Espectroscopia de Ressonância Magnética , Simulação de Acoplamento Molecular , Estrutura Molecular , Paclitaxel/metabolismo , Tubulina (Proteína)/metabolismo
6.
Steroids ; 78(9): 866-73, 2013 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-23685088

RESUMO

Hurgadacin (1), a 24,25-bishomo-26-methylenecholesterol was isolated from the soft coral Sinularia polydactyla, collected from the Red Sea, near Hurghada at the Egyptian coast. The new steroid 1 was isolated together with the closely related polyhydroxy steroids 24-methylenecholestane-3ß,5α,6ß-triol (2) and 24-methylenecholestane-1α,3ß,5α,6ß,11α-pentol (3), in addition to the sesquiterpene lactiflorenol (4) and the trinorcarotenolide acetate peridinin (5), The structures of the isolated compounds were confirmed by intensive studies of their 1D and 2D NMR spectra and mass data. The antimicrobial and cytotoxic activities of the soft coral extract and the corresponding constituents were evaluated against diverse pathogenic microorganisms and brine shrimps, respectively.


Assuntos
Antozoários/química , Antibacterianos/química , Antifúngicos/química , Colesterol/análogos & derivados , Animais , Antibacterianos/isolamento & purificação , Antibacterianos/farmacologia , Antifúngicos/isolamento & purificação , Antifúngicos/farmacologia , Artemia , Bacillus subtilis/efeitos dos fármacos , Candida albicans/efeitos dos fármacos , Carotenoides/química , Carotenoides/isolamento & purificação , Chlorella vulgaris/efeitos dos fármacos , Colesterol/química , Colesterol/isolamento & purificação , Colesterol/farmacologia , Testes de Sensibilidade a Antimicrobianos por Disco-Difusão , Escherichia coli/efeitos dos fármacos , Conformação Molecular , Mucor/efeitos dos fármacos , Pythium/efeitos dos fármacos , Rhizoctonia/efeitos dos fármacos , Staphylococcus aureus/efeitos dos fármacos , Streptomyces/efeitos dos fármacos
7.
Org Med Chem Lett ; 2(1): 30, 2012 Aug 16.
Artigo em Inglês | MEDLINE | ID: mdl-22898269

RESUMO

BACKGROUND: More than 15,000 marine products have been described up to now; Sponges are champion producers, concerning the diversity of products that have been found. Most bioactive compounds from sponges were classified into anti-inflammatory, antitumor, immuno- or neurosurpressive, antiviral, antimalarial, antibiotic, or antifouling. Evaluation of in vitro inhibitory effects of different extracts from four marine sponges versus some antioxidants indices and carbohydrate hydrolyzing enzymes concerned with diabetes mellitus was studied. The chemical characterizations for the extracts of the predominating sponges; SP1 and SP3 were discussed. METHODS: All chemicals served in the biological study were of analytical grade and purchased from Sigma, Merck and Aldrich. All kits were the products of Biosystems (Spain), Sigma Chemical Company (USA), Biodiagnostic (Egypt). Carbohydrate metabolizing enzymes; α-amylase, α-glucosidase, and β-galactosidase (EC3.2.1.1, EC3.2.1.20, and EC3.2.1.23, respectively) were obtained from Sigma Chemical Company (USA). RESULTS: Four marine sponges; Smenospongia (SP1), Callyspongia (SP2), Niphates (SP3), and Stylissa (SP4), were collected from the Red Sea at Egyptian coasts, and taxonomically characterized. The sponges' extracts exhibited diverse inhibitory effects on oxidative stress indices and carbohydrate hydrolyzing enzymes in linear relationships to some extent with concentration of inhibitors (dose dependant). The extracts of sponges (3, 1, and 2) showed, respectively, potent-reducing power. Purification and Chemical characterization of sponge 1 using NMR and mass spectroscopy, recognized the existence of di-isobutyl phthalate (1), di-n-butyl phthalate (2), linoleic acid (3), ß-sitosterol (4), and cholesterol (5). Sponge 3 produced bis-[2-ethyl]-hexyl-phthylester (6) and triglyceride fatty acid ester (7). CONCLUSION: Marine sponges are promising sources for delivering of bioactive compounds. Four marine sponges, collected from Red Sea at Egyptian coasts, were identified as Smenospongia (SP1), Callyspongia (SP2), Niphates (SP3), and Stylissa (SP4). The results demonstrated that different sponges extracts exhibited inhibitory effects on oxidative stress indices and carbohydrate hydrolyzing enzymes in linear relationships to some extent with concentration of inhibitors (dose dependant). The extracts of sponges (3, 1, and 2) showed, respectively, potent-reducing power. Chemical characterizations of sponges SP1 and SP3 were discussed. Based on this study, marine sponges are considered as talented sources for production of diverse and multiple biologically active compounds.

8.
Chem Biodivers ; 7(12): 2880-7, 2010 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-21162000

RESUMO

Two new brominated compounds, subereaphenol K (2) and 2-(3,5-dibromo-1-ethoxy-4-oxocyclohexa-2,5-dien-1-yl)acetamide (3), together with subereaphenol B (methyl 2-(2,4-dibromo-3,6-dihydroxyphenyl)acetate; 1) with a revised structure, and five dibromotyrosine-derived metabolites, 4-8, were isolated from the sponge Suberea sp. and characterized by 1D- and 2D-NMR spectroscopic and HR-MS spectrometric data. Compounds 1, 2, 6, and 8 exhibited various weak or moderate bioactivities, including antimicrobial and cytotoxic activities. Furthermore, compounds 1 and 2 inhibited human recombinant phosphodiesterase 4 (PDE4) with IC50 values of 2 µM, whereas compounds 6 and 8 were less active.


Assuntos
Acetamidas/química , Nucleotídeo Cíclico Fosfodiesterase do Tipo 4/química , Cicloexanonas/química , Hidrocarbonetos Bromados/química , Fenilacetatos/química , Poríferos/química , Acetamidas/isolamento & purificação , Acetamidas/toxicidade , Animais , Antibacterianos/química , Antibacterianos/isolamento & purificação , Antibacterianos/toxicidade , Nucleotídeo Cíclico Fosfodiesterase do Tipo 4/metabolismo , Cicloexanonas/isolamento & purificação , Cicloexanonas/toxicidade , Humanos , Hidrocarbonetos Bromados/metabolismo , Hidrocarbonetos Bromados/toxicidade , Espectroscopia de Ressonância Magnética , Testes de Sensibilidade Microbiana , Conformação Molecular , Fenilacetatos/isolamento & purificação , Fenilacetatos/toxicidade , Inibidores da Fosfodiesterase 4/química , Inibidores da Fosfodiesterase 4/isolamento & purificação , Inibidores da Fosfodiesterase 4/toxicidade , Poríferos/metabolismo
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