1.
Blood
; 102(4): 1551-2, 2003 Aug 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12900353
Assuntos
ADP-Ribosil Ciclase/sangue , Antígenos CD34/sangue , Antígenos CD/sangue , Células-Tronco Hematopoéticas/citologia , Mosaicismo/genética , Mielofibrose Primária/genética , ADP-Ribosil Ciclase 1 , Citometria de Fluxo , Humanos , Hibridização in Situ Fluorescente , Cariotipagem , Leucócitos/citologia , Glicoproteínas de Membrana , Mosaicismo/imunologia , Mielofibrose Primária/imunologia
2.
Br J Haematol
; 119(1): 109-11, 2002 Oct.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12358910
RESUMO
The Abl kinase inhibitor STI571 (imatinib mesylate) induces haematological remissions in many patients with chronic myeloid leukaemia (CML) but advanced stage CML usually becomes resistant to STI571. We describe a patient in whom progressive resistance to STI571 correlated with the appearance of a mutation in the Bcr-Abl kinase domain. This was a G to A transition that resulted in a glutamic acid to lysine substitution at position 255 (E255K) in the Abl type 1a protein. We suggest that the acquisition of point-mutations in the tyrosine kinase domain of Bcr-Abl may cause progressive clinical resistance to STI571.