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Dessensibilização Imunológica/métodos , Extratos Vegetais/imunologia , Rinite Alérgica Sazonal/terapia , Adolescente , Adulto , Idoso , Criança , Protocolos Clínicos , Feminino , Humanos , Hipersensibilidade Imediata , Infusões Subcutâneas , Masculino , Pessoa de Meia-Idade , Poaceae/imunologia , Rinite Alérgica Sazonal/imunologia , Resultado do Tratamento , Adulto JovemRESUMO
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Assuntos
Criança , Adolescente , Adulto Jovem , Adulto , Pessoa de Meia-Idade , Idoso , Dessensibilização Imunológica/métodos , Segurança do Paciente , Conjuntivite Alérgica/etiologia , Rinite/imunologia , Rinite Alérgica Sazonal/imunologia , Extratos Vegetais/imunologia , Alérgenos/imunologia , Injeções Subcutâneas , Tolerância Imunológica/imunologia , Extratos Vegetais/uso terapêuticoRESUMO
Complete heart block associated with Wegener's granulomatosis (WG) is rare, and has not previously been reported with 'limited' WG. The case of a 36-year-old man who presented with complete heart block due to 'limited' WG [positive cytoplasmic antineutrophil cytoplasmic antibodies (c-ANCA) on indirect immunofluorescence, positive serum antibodies to proteinase-3, and inflammatory sinus disease seen on computerized tomography (CT) without renal or pulmonary involvement] is presented. In addition, a gallium-scan fused with a myocardial perfusion scan and cardiac magnetic resonance imaging (MRI) suggested focal inflammation near the atrioventricular (AV) node.
Assuntos
Anticorpos Anticitoplasma de Neutrófilos/análise , Granulomatose com Poliangiite/complicações , Granulomatose com Poliangiite/diagnóstico , Bloqueio Cardíaco/complicações , Bloqueio Cardíaco/diagnóstico , Adulto , Eletrocardiografia , Ensaio de Imunoadsorção Enzimática , Seguimentos , Humanos , Imageamento por Ressonância Magnética , Masculino , Doenças Raras , Medição de Risco , Índice de Gravidade de Doença , Tomografia Computadorizada por Raios XRESUMO
OBJECTIVE: To investigate the effects of cigarette smoking and alcohol consumption on the development of systemic lupus erythematosus (SLE). METHODS: We interviewed 125 patients with SLE and 125 controls in a case-control study. Demographically similar controls randomly selected from outpatient clinics were matched to SLE cases for sex and age. Clinical data, including cigarette smoking, drinking habits, and other demographic variables, were collected by an interview-administered questionnaire. RESULTS: To minimize bias associated with reactive habits induced by disease, cigarette smoking before the diagnosis of SLE was the primary variable for subsequent analysis. Analysis of the data by multivariate conditional logistic regression revealed that both cigarette smoking before SLE diagnosis and ex-smoking before SLE diagnosis significantly increased the risk of development of SLE (OR 6.69, 95% CI 2.59, 17.28, p < 0.001; and OR 3.62, 95% CI 1.22, 10.70, p = 0.02, respectively). This association remained even when statistically controlling for the effects of family history and education, indicating an independent effect. Alcohol did not place an individual at increased risk nor did it have a protective role. CONCLUSION: The results of this study provide further evidence that cigarette smoking may be an associated risk factor for the development of SLE.
