Minimally invasive ablation of a toxic thyroid nodule by high-intensity focused ultrasound.

HIFU is used in the treatment of cancer (prostate, breast) and uterine fibroma but not yet in TNs. This case report describes the first successful ablation of a toxic TN with HIFU. TSH and radioiodine scan normalization were achieved without complications and maintained for 18 months. HIFU treatment is a minimally invasive technique that may be an effective safe alternative to radioiodine or surgery in patients with toxic TNs.

[Lutenyl and menstrual disorders. A hospital study]. / Lutényl et les troubles des règles. Etude hospitalière.

The efficacy of nomegestrol acetate in the treatment of menstrual cycle disorders and dysfunctional uterine bleedings was confirmed on 66 cases in this study conducted by three hospital departments. The study also confirmed the perfect clinical tolerance of nomegestrol acetate. One knows that the same is not true with Nortestosterone derivatives which were used up to now in these indications.

[Residual ovarian function after minidoses of estroprogestative agents]. / Etude de la fonction ovarienne résiduelle sous estroprogestatifs minidosés.

Levels of plasma 17 beta oestradiol, FSH and LH, were carried out on the 7th, 14th, 21st and 28th day of the cycle in three studies in order to evaluate the residual ovarian secretions under the influence of low-dose pills (30 micrograms of ethinyl-oestradiol and 150 micrograms of levonorgestrel). The studies consisted of: a preliminary study involving 5 women under the oestrogen/progestogen pills over more than 1 year; a comparative study of the three first cycles on the same preparation against a control cycle (5 women); a comparative crossover study of one cycle of the minidose oestrogen/progestogen preparation and one cycle of oestrogen/progestogen preparation with 50 micrograms of ethinyl-oestradiol (10 women). The results of these trials show that minidose oestrogen/progestogen preparations have a braking effect on the hypophysio-ovarian axis similar to that exerted by the higher dose pills.

[Synthetic progestogens (author's transl)]. / Les progestatifs de synthèse.

Synthetic progestogens are divided into three major groups of steroids which derive from the basic steroid nucleus. Several routes of administration can be used. The characteristics (progestomimetic, progestational, and hormonal) of the different progestogens are variable. The different compounds are therefore of therapeutic value in specific indications. For some of these a study of the literature was carried out. We studied : anomalies of the menstrual cycle (involving chronology, menstruation...); the premenstrual syndrome with or without benign mastopathy ; menopause (premenopause and established menopause). The differences in the tolerance of the different compounds in use are recalled, in connexion with contra-indications and major and minor side-effects. The wide differences between the various compounds can make the choice of the less than right progestogen greater than difficult.

[Effects of progestogens on the metabolism of lipids and carbohydrates. Practical consequences (author's transl)]. / Effets des progestatifs sur le métabolisme des lipides et des glucides. Conclusions pratiques.

Estrogens which are one of the components of contraceptive less than pills greater than are incriminated in many cardiovascular accidents. These occur as a result of metabolic disorders (involving lipids and carbohydrates), of modifications in coagulation factors, etc. The possible influence of progestogens was ignored for a long time. The widespread use of these compounds, prescribed for contraception as well as during hormonal replacement therapy for absolute or relative luteinic insufficiency, makes careful monitoring of lipid and carbohydrate metabolism imperative. This position is strengthened by a preliminary review of the literature which leads to several conclusions concerning lipid and carbohydrate metabolism.

PIP: Estrogens, which are among the components of contraceptive pills, are incriminated in many cardiovascular accidents. These occur as a result of metabolic disorders (involving lipids and carbohydrates), of modifications in coagulation factors, etc. The possible influence of progestogens was ignored for a long time. The widespread use of these compounds, prescribed for contraception as well as during hormonal replacement therapy for absolute or relative luteinic insufficiency, makes careful monitoring of lipid and carbohydrate metabolism imperative. This position is strengthened by a preliminary review of the literature which leads to several conclusions concerning lipid and carbohydrate metabolism. (author's)