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Exp Hematol ; 107: 20-23, 2022 03.
Artigo em Inglês | MEDLINE | ID: mdl-34952139

RESUMO

The Covid-19 pandemic has caused millions of deaths worldwide. Although vaccines have been developed, patients on immunosuppressive therapy are less likely to respond. This study was aimed at investigating the efficacy of a Covid-19 vaccine (Pfizer-BioNTech) in patients with non-Hodgkin lymphoma treated with anti-CD20 monoclonal antibodies. Only 1 of 28 lymphoma patients (3.6%) developed a seropositive response, compared with 100% (28/28) of the healthy volunteers. The low levels of CD19+ lymphocytes among the lymphoma patients suggest that anti-CD20 treatment prevents the seropositive response to the vaccine. An additional vaccination might be indicated in these patients once B cells are repopulated.


Assuntos
COVID-19 , Linfoma não Hodgkin , Anticorpos Monoclonais/uso terapêutico , COVID-19/prevenção & controle , Vacinas contra COVID-19 , Humanos , Linfoma não Hodgkin/tratamento farmacológico , Pandemias , SARS-CoV-2 , Vacinação
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