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1.
Arch Gynecol Obstet ; 309(2): 413-425, 2024 02.
Artigo em Inglês | MEDLINE | ID: mdl-37179498

RESUMO

OBJECTIVE: The objective of our study is to estimate the prevalence of endometrial cavity fluid (ECF) in Assisted Reproductive Techniques (ART) cycles and analyze its effects on pregnancy outcome in such cycles. DATA SOURCES: PubMed, Cochrane Central, Scopus, and clinicaltrials.gov were searched for articles. The reference lists of relevant publications were explored for other studies. STUDY ELIGIBILITY CRITERIA: Studies that had assessed the pregnancy outcome in ART cycles and had commented on ECF accumulation were included. Pregnancy outcomes were assessed in all ART cycles where ECF was observed and were compared to the non-ECF cycles. RESULTS: A total of nine studies were included in the meta-analysis for a total of 28,210 cycles. Pooled analysis of the prevalence of ECF cycles out of total cycles in females undergoing ART using a fixed effect model showed that it was 14% (95% CI is 13% to 14%; I2 = 99%, p = < 0.01). The random effect model prevalence of ECF cycles was around 7% (95% CI: 4% to 10%). There was a statistically significant (25%) decrease in pregnancy rates per cycle transfer in the ECF cycle versus the non-ECF cycle group during ART [OR = 0.75, 95% CI = 0.67-0.84), p < 0.001; moderate quality evidence]. When ECF size was compared, there was a statistically significant increase in pregnancy rates if ECF size was less than 3.5 mm versus greater than or equal to 3.5 mm [OR = 13.67, 95% CI = 1.43-130.40), p = 0.02; high quality evidence]. Sub-group analysis revealed that the ECF present at the time of embryo transfer significantly decreased the pregnancy rates by 26% as compared to the group where the ECF was not present at the time of embryo transfer [OR = 0.74, 95% CI = 0.65-0.85), p < 0.001]. CONCLUSIONS: This meta-analysis proposes that the presence of ECF significantly decreases the implantation and pregnancy rates of ART cycles, and even more so if its size is greater than 3.5 mm. Interventions to decrease ECF formation or treat it have enhanced the pregnancy outcome in ART cycles. PROSPERO REGISTRATION: Date: 17th September 2020; Number: CRD42020182262.


Assuntos
Endométrio , Nascido Vivo , Humanos , Feminino , Gravidez , Nascido Vivo/epidemiologia , Técnicas de Reprodução Assistida , Resultado da Gravidez , Taxa de Gravidez , Fertilização in vitro
2.
Am J Obstet Gynecol ; 2023 Dec 25.
Artigo em Inglês | MEDLINE | ID: mdl-38151222

RESUMO

This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/policies/article-withdrawal.

3.
Obstet Gynecol Sci ; 66(4): 316-326, 2023 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-37073604

RESUMO

OBJECTIVE: Due to its comprehensive, reliable, and valid format, the objective structured clinical examination (OSCE) is the gold standard for assessing the clinical competency of medical students. In the present study, we evaluated the importance of the OSCE as a learning tool for postgraduate (PG) residents assessing their junior undergraduate students. We further aimed to analyze quality improvement during the pre-coronavirus disease (COVID) and COVID periods. METHODS: This quality-improvement interventional study was conducted at the Department of Obstetrics and Gynecology. The PG residents were trained to conduct the OSCE. A formal feedback form was distributed to 22 participants, and their responses were analyzed using a five-point Likert scale. Fishbone analysis was performed, and the 'plan-do-study-act' (PDSA) cycle was implemented to improve the OSCE. RESULTS: Most of the residents (95%) believed that this examination system was extremely fair and covered a wide range of clinical skills and knowledge. Further, 4.5% believed it was more labor- and resource intensive and time-consuming. Eighteen (81.8%) residents stated that they had learned all three domains: communication skills, time management skills, and a stepwise approach to clinical scenarios. The PDSA cycle was run eight times, resulting in a dramatic improvement (from 30% to 70%) in the knowledge and clinical skills of PGs and the standard of OSCE. CONCLUSION: The OSCE can be used as a learning tool for young assessors who are receptive to novel tools. The involvement of PGs in the OSCE improved their communication skills and helped overcome human resource limitations while manning various OSCE stations.

4.
Health Care Women Int ; 44(4): 487-495, 2023 04.
Artigo em Inglês | MEDLINE | ID: mdl-36264177

RESUMO

Hysterosalpingography (HSG) is the first-line investigation in infertility assessment to assess tubal patency. Clinicians use various instruments, including the Leich-Wilkinson cannula, Rubin cannula, Jorcho's cannula, Whitehead cannula, and foley's catheter, to instill the dye in the uterus. We randomly allocated 60 patients planned for hysterosalpingography to evaluate tubal patency as part of fertility workup to either Intra-uterine foley's catheter arm or Leich-Wilkinson cannula arm. The research team measured and compared immediate and delayed numerical pain scores in both arms. We observed significantly lower pain scores in Foley's catheter arm as compared to the Leich-Wilkinson arm for both early (5.7 ± 3.01 vs. 7.8 ± 1.95) and delayed (0.15 ± 0.37 vs. 0.40 ± 0.50) evaluation. We established that using a Foley catheter for the HSG procedure was associated with lesser pain to the patient, with no evident difference regarding imaging of the uterus and tubes.


Assuntos
Histerossalpingografia , Infertilidade Feminina , Feminino , Humanos , Histerossalpingografia/métodos , Cânula , Útero , Dor , Catéteres
5.
Int J Gynaecol Obstet ; 160(2): 698-706, 2023 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-35965397

RESUMO

OBJECTIVES: To derive a prediction model combining various clinical factors associated with increased risk of emergency cesarean section following induction of labor in women with unfavorable cervix. METHODS: All women with singleton term pregnancies undergoing induction of labor and fulfilling inclusion criteria were included in this cross-sectional study after supplying consent. Women with a Bishop score of 6 or less were induced with dinoprostone gel. Multiple regression analysis was used to find the most significant independent predictive factors and these factors were used to develop the predictive model and calculator. RESULTS: After multiple logistic regression, risk of emergency cesarean after induction of labor was significantly associated with the following variables: height (adjusted odds ratio [aOR] 0.955, P = 0.033), nulliparity (aOR 3.987, P < 0.001), closed cervix (aOR 2.030, P = 0.030), fetal station -3 above ischial spine (aOR 2.719, P = 0.043), firm or medium cervical consistency (aOR 2.028, P = 0.004), cervical length 3 cm or longer (aOR 3.090, P = 0.015), posterior cervix (aOR 2.112, P = 0.002). CONCLUSION: Use of a prediction model would help to reduce the number of emergency cesarean sections secondary to unsuccessful inductions and help in the reduction of maternal and perinatal morbidity.


Assuntos
Cesárea , Trabalho de Parto , Gravidez , Feminino , Humanos , Estudos Transversais , Trabalho de Parto Induzido/efeitos adversos , Paridade
6.
J Hum Reprod Sci ; 16(4): 317-323, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-38322633

RESUMO

Background: There is ongoing research to find an optimum modality to predict male fertility potential. Aims: To compare the semen parameters, sperm DNA damage and seminal metal levels of Zinc, Lead and Aluminium among the male partners of couples with unexplained infertility and men with proven fertility. Settings and Design: Prospective case-control study at a tertiary level teaching hospital. Materials and Methods: One hundred male partners of couples with unexplained subfertility and 50 men with proven fertility were included in the study. Male partners of unexplained infertility couples and fertile men were compared for their semen parameters, sperm DNA Fragmentation Index (DFI) and seminal metal levels in semen. Statistical Analysis Used: Chi-square test, Student's t-test, sensitivity and specificity analysis, binomial logistic regression analysis. Results: Fertile men had statistically significantly higher mean progressive sperm motility than male partners of unexplained infertility (53.12 ± 9.89% vs. 44.81 ± 19.47%, P = 0.005). Semen volume and sperm concentration were comparable among the cases and control population. The mean sperm DFI was significantly lower among fertile men (10.83 ± 6.28 vs. 21.38 ± 10.28, P < 0.0001). Plotting the receiver-operating characteristic curve the threshold for discrimination was calculated to be 18% DFI. The sensitivity specificity and overall accuracy were 43%, 84% and 56.67%, respectively when the DFI cut-off was set at 18%. Zinc concentration in the semen had a strong positive correlation (Point Biserial correlation coefficient = 0.831) with fertility, whereas lead and aluminium had a moderate negative correlation. Conclusion: Conventional semen analysis had limited differentiating ability for unexplained infertility. The sperm DFI may be employed for explanatory purposes among couples with unexplained subfertility. A lower discriminatory threshold of DFI (18%) has better overall accuracy as opposed to a 30% cutpoint for unexplained subfertility. Among metals, Zinc was strongly correlated with fertility status.

7.
Int J Gynaecol Obstet ; 158(1): 153-161, 2022 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-34541664

RESUMO

OBJECTIVE: To measure the anatomical dimensions of the vulva in adult Indian women. To analyze their correlations with age, body mass index (BMI), parity, and mode of delivery. METHODS: This cross-sectional study was conducted in a tertiary care university hospital in India, among 400 women aged 18 years and above. Various vulval measurements were taken, and Pearson's correction was applied to variables like age, BMI, parity, and mode of delivery. RESULTS: Mean length of glans of clitoris was 5.2 ± 1.43 mm, the labia minora width was 2.6 ± 0.74 cm, length of introitus was 1.3 ± 0.59 cm, and perineal body length was 2.3 ± 0.60 cm. The range of some measurements was extensive, for example labia minora width ranged from 0.7 to 4.9 cm. Normal centile curves were constructed for vulval measurements according to age groups. Statistically significant positive correlations of age, BMI, and obstetrical history were seen with labia minora width (r = 0.165, P = 0.001; r = 0.284, P < 0.001; r = 0.246, P < 0.001, respectively). CONCLUSION: The centile curves can be used as a reference for the Indian population of different ages. These can be used when counseling women coming for female genital cosmetic surgery.


Assuntos
Vulva , Adulto , Clitóris/anatomia & histologia , Estudos Transversais , Feminino , Procedimentos Cirúrgicos em Ginecologia/métodos , Humanos , Estudos Prospectivos , Cirurgia Plástica , Vulva/anatomia & histologia
8.
Fam Syst Health ; 39(4): 576-587, 2021 12.
Artigo em Inglês | MEDLINE | ID: mdl-34735213

RESUMO

INTRODUCTION: The study aimed to assess the perceived quality of life (QOL) and to estimate the prevalence of depression among infertile couples as well as to study the congruence of the outcome among both partners. The sociodemographic factors influencing these outcomes were also examined. METHOD: A prospective, cross-sectional study of 130 infertile couples over 1 year at a tertiary level teaching hospital. Couples were requested to complete the WHOQOL-BREF instrument and Beck Depression Inventory (BDI). Data was analyzed using paired t test, 1-way multivariate linear variance analysis, and regression, and correlation models. RESULTS: Mean QOL scores between men and women showed a strong agreement within psychological, social, environmental, and physical domains (r = .70, .67, .69, and .59 likewise). The presence of depressive symptoms was associated with significantly impaired QOL scores through all domains. Depression was present in 30.6% of female partners and 27.2% in male partners. Pearson correlation between female partner BDI scores and male partner scores was highly statistically significant with a correlation coefficient of .745. The presence of depression was not found to be significantly associated with sociodemographic and clinical parameters. CONCLUSIONS: QOL and depression scores of 1 partner were reflected in the scores of the other partner. Henceforth, screening and psychoeducation should be couple based considering the couple as 1 unit which is likely to improve the mental wellbeing of the couple. The presence of depression is not influenced by the sociodemographic profile of couples therefore all infertile couples should be screened and offered counseling. (PsycInfo Database Record (c) 2021 APA, all rights reserved).


Assuntos
Depressão , Qualidade de Vida , Estudos Transversais , Depressão/epidemiologia , Feminino , Humanos , Masculino , Estudos Prospectivos , Fatores Sociodemográficos , Inquéritos e Questionários
9.
J Midlife Health ; 12(4): 316-318, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-35264840

RESUMO

Postmenopausal bleeding is one of the common presenting complaints in the gynecological outpatient department. The common causes of which are atrophic endometritis, vaginitis, estrogen therapy, cancer endometrium, and cancer cervix. Hereby, we present a rare case of a 65-year-old female presented with postmenopausal bleeding who had history of trauma 1 year back with pelvic bone fracture. The cause of postmenopausal bleeding, in this case, is abnormal bony protrusion secondary to malunited pelvic fracture causing laceration of the right lateral vaginal wall. The case was managed by local osteotomy and vaginal wall repair.

10.
Pan Afr Med J ; 37: 62, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33244325

RESUMO

The pandemic of COVID-19 has proved to be a global catastrophe. Pregnant females could be more vulnerable to the infection owing to the immune modulation. According to the World Health Organization (WHO), pregnant females including those with COVID-19 suspicion or confirmed status have right to 'safe and positive childbirth experience' which includes a companion. The birth companion, is present at all times with the patient, from the initiation of labor till breastfeeding. The COVID-19 crisis has taken its toll on the healthcare system. The number of infected antenatal females are expected to increase. If a birth companion is trained in basic intrapartum and postpartum observation and care, he/she can be utilised to minimize unnecessary patient-clinician interface and optimize manpower in this critical time.


Assuntos
COVID-19/epidemiologia , Pandemias , Parto/psicologia , SARS-CoV-2 , Visitas a Pacientes/psicologia , Infecções Assintomáticas , COVID-19/prevenção & controle , Cesárea , Protocolos Clínicos , Feminino , Humanos , Consentimento Livre e Esclarecido , Masculino , Leite Humano , Isolamento de Pacientes , Gravidez , Complicações Infecciosas na Gravidez , Gestantes , Quarentena , Visitas a Pacientes/educação
11.
Eur J Obstet Gynecol Reprod Biol ; 253: 225-231, 2020 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-32889329

RESUMO

OBJECTIVE(S): Current evidence suggests that endometrial injury improves clinical pregnancy rate while having no effect on miscarriages in women undergoing IVF/ICSI. However, there is no substantial evidence to advocate the use of endometrial injury to benefit the outcomes of IUI treatment. Additionally, there is no clear consensus about the ideal timing, underlying mechanism and optimum intensity of endometrial injury required. The study examines the effect of intentional endometrial injury/scratch in the early proliferative phase of stimulated cycle on reproductive outcomes (clinical and ongoing pregnancy rates and miscarriage occurrence) of intra-uterine insemination treatment (IUI). STUDY DESIGN, SIZE, DURATION: This prospective, randomized control interventional study was conducted in a tertiary level teaching institution from April 2018 to February 2020. 150 eligible couples requiring IUI treatment who agreed to participate were randomly allocated on 1:1 basis to either control or intervention group. The trial participants received up to 3 cycles ovulation induction with clomiphene citrate and intra-uterine insemination. In addition, women in intervention group were subjected to endometrial scratch injury on day 6-7 of their stimulated cycle. 154 cycles in control arm and 128 cycles in intervention group were analyzed for clinical pregnancy, miscarriages and pain experienced by the women during endometrial scratch injury using the statistical package SPSS (version 21). RESULT: Similar cumulative clinical pregnancy rates (12.5% Vs 13.6%, RR 1.21, 95% CI 0.44-3.37, p = 0.713), biochemical pregnancy rates (17.1% vs 22.9%, RR 1.43, CI 0.59-3.47, p = 0.421) and ongoing pregnancy rates (10.93% Vs 11.47%, RR 1.05, CI 0.35-3.21, p = 924) were observed in control and intervention arms. Likewise, the relative risk of miscarriage occurrence in the intervention arm was 1.32 (95% CI 0.39-4.32, p = 1.000) which was not statistically different from control group. Mean pain score of 6.93 on numerical pain rating scale was experienced by women whilst having endometrial scratch injury. CONCLUSIONS: There is insufficient evidence to defend the use of endometrial scratch injury in intra-uterine insemination treatment, as it is moderately painful and have uncertain beneficial influence on reproductive outcomes.


Assuntos
Endométrio , Fertilização in vitro , Feminino , Humanos , Inseminação , Inseminação Artificial , Indução da Ovulação , Gravidez , Taxa de Gravidez , Estudos Prospectivos
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