Complex Regional Pain Syndrome Type I: Evidence for the CB1 and CB2 Receptors Immunocontent and Beneficial Effect of Local Administration of Cannabidiol in Mice.

Introduction: Complex regional pain syndrome type I (CRPS-I) is a debilitating neuropathic painful condition associated with allodynia, hyperalgesia, sudomotor and/or vasomotor dysfunctions, turning investigation of its pathophysiology and new therapeutic strategies into an essential topic. We aim to investigate the impact of ischemia/reperfusion injury on the immunocontent of CB1 and CB2 cannabinoid receptor isoforms in the paws of mice submitted to a chronic postischemia pain (CPIP) model and the effects of local administration of cannabidiol (CBD) on mechanical hyperalgesia. Methods: Female Swiss mice, 30-35 g, were submitted to the CPIP model on the right hind paw. Skin and muscle samples were removed at different periods for western blot analysis. Results: No changes in the immunocontent of CB1 and CB2 receptors in paw muscle tissues after ischemia-reperfusion were observed. CBD promoted an antihyperalgesic effect in both phases. AM281 reversed the effect of CBD, whereas ruthenium red abolished the late phase. Conclusion: Our results point to the possible beneficial effects of local administration of CBD in modulating CRPS-I in humans. As possible targets for CBD antihyperalgesia in this model, the contribution of cannabinoid receptor CB1, in addition to TRPM8 is suggested.

Effects of the application of a food processing-based classification system in obese women: A randomized controlled pilot study.

Background: Obesity is one of the major public health problems worldwide and contributes to the onset of many diseases, especially the ones related to the metabolic syndrome. The new Dietary Guidelines for the Brazilian population bring a new food classification based on food processing and prioritizes the consumption of fresh or minimally processed foods. Aim: This study analyzed the effects of an educational intervention on obese women, on their weight loss, quality of life, components of the metabolic syndrome and pain. Methods: Randomized controlled pilot study, including 40 obese women, randomized into 2 groups: control group and intervention group. An educational intervention with 5 biweekly meetings of 90 min based on the Dietary Guidelines for the Brazilian population (2014) was carried out involving the intervention group. Parameters related to weight loss, quality of life (SF-36), pain (McGill), bioelectrical impedance analysis, cardiorespiratory fitness, and serum and clinical components of metabolic syndrome, as well as serum concentrations of cytokines were assessed. Results: Significantly decrease of body mass, waist and hip circumferences, basal metabolic rate, extracellular water, body capacitance, and body cell mass were observed in the intervention group after 3 months. Reduction of pain and improvement in quality of life and cardiorespiratory fitness were also observed in the intervention group. There were reductions in waist circumference and glycemia, components of metabolic syndrome. Conclusions: This study showed that the educational intervention can be associated with weight loss, increase in quality of life, reduction of pain, and better metabolic syndrome parameters in obese women.

A carga das doenças cardiovasculares no estado de Santa Catarina no ano de 2009 / La carga de las enfermedades cardiovasculares en el estado de Santa Catarina en 2009 / The burden of cardiovascular diseases in Santa Catarina State, Brazil, in 2009

OBJETIVO: estimar a carga das doenças cardiovasculares no estado de Santa Catarina, Brasil. MÉTODOS: estudo ecológico cujas unidades de análise foram as nove macrorregiões de saúde do estado; foram estimados o número de anos de vida perdidos precocemente, o número de anos vividos com incapacidade e o número de anos de vida ajustados por incapacidade (DALYs) para 2009. RESULTADOS: foram estimados 358.777 DALYs, a uma taxa de 5.852 DALYs/100 mil habitantes, 51,1% no sexo masculino; as faixas etárias que apresentaram maiores taxas de DALYs foram as de 60-69, 70-79 e 45-59 anos; as doenças que mais contribuíram para DALYs foram doenças isquêmicas do coração e cerebrovasculares; as macrorregiões com maiores taxas de DALYs foram Planalto Norte, Sul e Serra Catarinense. CONCLUSÃO: a alta carga das doenças cardiovasculares em Santa Catarina evidencia a necessidade de intensificar as ações de promoção de saúde e de prevenção em todas as macrorregiões do estado.

OBJETIVO: estimar la carga de las enfermedades cardiovasculares en el estado de Santa Catarina, Brasil. MÉTODOS: estudio ecológico cuyas unidades de análisis fueron las nueve macro-regiones de salud del estado; fueron estimados el número de años de vida perdidos, número, de años vividos con discapacidad y el número de años de vida ajustados por discapacidad (DALYs) para 2009. RESULTADOS: fueron estimados 358.777 DALYs con tasa de 5.852 DALYs/100.000 habitantes, 51,1% en hombres y 48,9% en mujeres; los grupos de edad con las tasas más altas fueron 60-69 años, 70-79 años y 45-59 años; las enfermedades que más contribuyeron com DALYs fueron cardiopatías isquémicas y enfermedades cerebrovasculares; las macro-regiones con tasas de DALYs más altas fueron Planalto Norte, Sur y la Sierra Catarinense. CONCLUSIÓN: la carga de las enfermedades cardiovascular es alto y destaca la necesidad de intensificar acciones y políticas de promoción de la salud y prevención en todas las macro regiones del estado.

OBJECTIVE: to estimate the burden of cardiovascular diseases in Santa Catarina State, Brazil. METHODS: this is an ecological study with the nine health macroregions of the state as units of analysis; the number of years of life lost, the number of years lived with disability and the number disability-adjusted life years (DALYs) for 2009 were estimated. RESULTS: a total of 358,777 DALYs were estimated, with a rate of 5,852 DALYs/100,000 inhabitants, 51.1% in males; age groups with the highest rates were 45-59, 60-69, and 70-79 years; diseases that most contributed to the DALYs were ischemic heart diseases and cerebrovascular diseases; health regions with the highest DALYs rates were Planalto Norte, Sul and Serra Catarinense. CONCLUSION: the high burden of cardiovascular diseases in Santa Catarina shows the need to intensify actions of health promotion and prevention in all regions of the state.

The burden of cardiovascular diseases in Santa Catarina State, Brazil, in 2009. / A carga das doenças cardiovasculares no estado de Santa Catarina no ano de 2009.

OBJECTIVE: to estimate the burden of cardiovascular diseases in Santa Catarina State, Brazil. METHODS: this is an ecological study with the nine health macroregions of the state as units of analysis; the number of years of life lost, the number of years lived with disability and the number disability-adjusted life years (DALYs) for 2009 were estimated. RESULTS: a total of 358,777 DALYs were estimated, with a rate of 5,852 DALYs/100,000 inhabitants, 51.1% in males; age groups with the highest rates were 45-59, 60-69, and 70-79 years; diseases that most contributed to the DALYs were ischemic heart diseases and cerebrovascular diseases; health regions with the highest DALYs rates were Planalto Norte, Sul and Serra Catarinense. CONCLUSION: the high burden of cardiovascular diseases in Santa Catarina shows the need to intensify actions of health promotion and prevention in all regions of the state.