A double-blind comparison of nimesulide and mefenamic acid in the treatment of acute upper respiratory tract infections in children.

The efficacy and safety of nimesulide suspension were evaluated in comparison with mefenamic acid in a double-blind multicentre study that recruited 100 children with acute respiratory tract infections. On entry, each child was randomly allocated to receive either nimesulide 5 mg/kg/day or mefenamic acid 5 mg/kg divided into 2 or 3 daily doses as an oral suspension, for a period of 3 to 10 days. Body temperature returned to normal on the third day for most of the nimesulide-treated patients, but only on the fifth day for the mefenamic acid group. There was a significant difference (p < 0.01) between the antipyretic activity of nimesulide and that of mefenamic acid. Furthermore, treatment with nimesulide was associated with clinically significant improvement in all inflammatory signs and symptoms observed (rhinorrhoea, nasal obstruction, pharyngeal redness, swelling of lymph nodes and cough). Adverse effects considered possibly related to treatment were recorded for 3 patients treated with nimesulide and 1 with mefenamic acid.

[The mucocutaneous lymph node syndrome (Kawasaki syndrome). A case with gallbladder hydrops and coronary artery aneurysm]. / Das mukokutane Lymphknotensyndrom (Kawasaki-Syndrom). Beschreibung eines Falles mit Hydrops der Gallenblase und Aneurysma einer Koronararterie.

Report on a case of mucocutaneous lymph node syndrome (Kawasaki disease) with typical course, transient hydrops of the gallbladder and aneurysmatic dilatation of the left coronary artery diagnosed by bidimensional echocardiography. Diagnosis and therapy of the disease are discussed.

Development of visual discrimination (pattern preference) in normal infants.

Visual discrimination for vertical stripes versus an unpatterned visual stimulus (plain grey) was studied longitudinally in 75 "normal" infants born at term, at monthly intervals from 1 to 6 months of age. Total fixation time was found to progressively decrease with increasing age, with a very sharp jump between the values of 2 and 3 months. Correspondingly, the mean duration of a single fixation decreased. The number of single fixations increased by age, doubling at 6 months in comparison to 1 month. A preferential fixation for stripes was already evident at the age of 1 month. A probabilistic method for assessing discrimination in individuals is proposed. The values will be correlated with follow-up results of cognitive development until school-age.