RESUMO
The effects of 2',4'-dihydroxychalcone and 2',4'-dihydroxy-3'-methoxychalcone from Zuccagnia punctata Cav. (Fabaceae) and melatonin administration on ethanol-induced gastroduodenal injury were investigated in rats. Both chalcones showed significant preventive effects in treatment with melatonin previous to the necrotising agent. These effects could be due, in part, to the radical scavenging activity of the melatonin.
Assuntos
Antioxidantes/uso terapêutico , Chalcona/análogos & derivados , Chalcona/uso terapêutico , Fabaceae , Gastroenteropatias/prevenção & controle , Melatonina/uso terapêutico , Fitoterapia , Extratos Vegetais/uso terapêutico , Análise de Variância , Animais , Chalcona/química , Chalcona/isolamento & purificação , Chalconas , Etanol , Gastroenteropatias/induzido quimicamente , Masculino , Extratos Vegetais/química , Extratos Vegetais/isolamento & purificação , Ratos , Ratos WistarRESUMO
A pharmacological evaluation of Zuccagnia punctata Cav. (Fabaceae) on the gastrointestinal tract was made in rats and mice. 2',4'-dihydroxychalcone and 2',4'-dihydroxy-3'-methoxychalcone were isolated from Zuccagnia punctata. The data reported in the present work indicate that the acetone extract and infusion of Zuccagnia punctata reduced intestinal transit in rats and mice and offered protection against ethanol-induced ulceration in rats. The Z. punctata effect could be due, in part, to the presence of 2',4'-dihydroxychalcone and 2',4'-dihydroxy-3'-methoxychalcone in this plant.
