RESUMO
Chronic periodontitis is a multifactorial inflammatory disease that affects supporting structures of the teeth. Although the gingival response is largely described, little is known about the immune changes in the alveolar bone and neighboring tissues that could indicate periodontal disease (PD) activity. Then, in this study we identified the ongoing inflammatory changes and novel biomarkers for periodontitis in the tissues directly affected by the destructive disease in PD patients. Samples were collected by osteotomy in 17 control subjects during extraction of third molars and 18 patients with advanced PD, in which alveoloplasty was necessary after extraction of teeth with previous extensive periodontal damage. Patients presented mononuclear cells infiltration in the connective tissue next to the bone and higher fibrosis area, along with increased accumulation of IL-17(+) and TRAP(+) cells. The levels of TNF-α and MMP-2 mRNA were also elevated compared to controls and a positive and significant correlation was observed between TNF-α and MMP-2 mRNA expression, considering all samples evaluated. In conclusion, nongingival tissues neighboring large periodontal pockets present inflammatory markers that could predict ongoing bone resorption and disease spreading. Therefore, we suggested that the detailed evaluation of these regions could be of great importance to the assessment of disease progression.
Assuntos
Periodontite Crônica/metabolismo , Interleucina-17/genética , Metaloproteinase 2 da Matriz/genética , Fator de Necrose Tumoral alfa/genética , Adulto , Biomarcadores , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , RNA Mensageiro/análise , Fator de Crescimento Transformador beta/genéticaRESUMO
Os autores apresentam dois casos clínicos de pacientes acometidos por Penfigóide Benigno de Mucosa (PBM), em que havia suspeita de "gengivite descamativa". O presente trabalho tem por objetivo, discutir a importância do reconhecimento do PBM por parte da classe odontológica e ressaltar a relevância do acompanhamento clínico prolongado, associado à utilização de técnicas adequadas de higiene oral e uso de corticosteróidestópicos
