1.
Chem Commun (Camb)
; 52(6): 1206-9, 2016 Jan 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26608754
RESUMO
An efficient sequential 1,2-addition/cross-coupling of Weinreb amides with two organolithium reagents is reported. This synthetic approach allows access to a wide variety of functionalized ketones in a modular way. The one-pot procedure presented here takes advantage of a kinetically stable tetrahedral Weinreb intermediate during subsequent Pd-catalyzed cross-coupling with the second organolithium reagent leading, within short reaction times and under mild conditions, to the formation of ketones in excellent overall yields.