1.
Bull Environ Contam Toxicol
; 85(4): 381-4, 2010 Oct.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20835703
RESUMO
The aim of this study was to identify a new putative biomarker in Salmo trutta exposed to water pollution. Variations in the levels of hepatic 3-hydroxy 3-methylglutaryl Coenzyme A reductase (HMG-CoAR), the rate-limiting enzyme of cholesterol biosynthesis, were compared to heat shock protein 70 and hypoxia inducible factor α, biomarkers of pollution exposure and lowered O2, respectively. The results confirm that HMG-CoAR levels increase in polluted water irrespective of water temperature or O2 content, indicating that HMG-CoAR could be used as a specific biomarker for water pollution.