[Changes in the indices of left ventricular filling in elderly patients with ischemic heart disease]. / Izmenenie pokazatelei napolneniia levogo zheludochka u bol'nykh ishemicheskoi bolezn'iu serdtsa pozhilogo vozrasta.

With the purpose of examining particular characteristics of filling of the left ventricle in elderly IHD patients we evaluated essentially healthy persons, both young and of greater age, and elderly IND patients (exertional angina, II-III functional class), 20 subjects in each of the three groups of examines, by echocardiography followed by the echocardiograms processing on a computer. The greatest age-related changes were found for the phase of early filling. Also noted in IHD patients was a relatively prolonged atrial systole and shortened time of filling, reduction in the value for the index "duration of slow filling/duration of fast filling", increase in the volume rate of blood filling in the phase of slow filling.

[Changes in left ventricular function in elderly hypertension patients]. / Izmenenie funktsii levogo zheludochka u bol'nykh gipertonicheskoi bolezn'iu pozhilogo vozrasta.

As many as 81 patients suffering from stage-II essential hypertension (EH) and 20 practically healthy persons of the same age were examined. EH patients manifested derangement of systolic function of the left ventricle, attested to by a decrease of contractility in the first third of the systole. The lowering of the velocity of active relaxation, change in the structure of the filling of the left ventricle coupled with a decrease of the role of the rapid filling phase and a rise of the contribution of the phases of slow filling and the atrial systole were noted. A decrease of the blood flow velocity at the phase of the atrial systole was also noted, which points to a decrease of the compensatory role of the left atrium in elderly patients. As compared to younger patients, compensatory hypertrophy of the left ventricle was pronounced relatively less in elderly patients. In these patients, compensatory potentialities of the hypertrophied left ventricle are preserved until the index of the left ventricular mass exceeds 170 g/m2. The further growth of that indicator is associated with a decline of the cardiac output.

[The efficacy of the captopril treatment of elderly hypertension patients]. / Effektivnost' lecheniia kaptoprilom bol'nykh gipertonicheskoi bolezn'iu pozhilogo vozrasta.

It was established that monotherapy with captopril was effective in 72% of patients with hypertensive disease in the elderly. Reduction of the arterial pressure is accompanied by an improvement of the indices of hemodynamics and myocardial contractility as well as relaxation of the left ventricle. Captopril proved more effective in patients with a high concentration of blood angiotensin. Acute load by a single intake of 25 mg of captopril may with high probability predict the efficacy of treatment courses, namely, in patients with a good clinical efficacy reduction of the preparation. Captopril is recommended for the treatment of hypertensive disease in the elderly.