[Effect of izoturon and its combination with ganglionic blockaders and alpha-adrenoblockaders on systemic hemodynamics in traumatic shock]. / Vliianie izoturona i ego kombinatsii s ganglioblokatorami i al'fa-adrenoblokatorami na sistemnuiu gemodinamiku pri travmaticheskom shoke.

Isoturone (5 mg/kg) administered in a single dose intravenously to unanesthetized cats in a torpid phase of traumatic shock increases arterial blood pressure (BP) and total peripheral vascular resistance (TPVR). The drug restores BP level mainly due to an increase of TPVR against background of neurovegetative blockade induced by pentamine, phentolamine and combinations of phentolamine with hexonium in the presence of a severe trauma. Vascular sensitivity to isoturone in traumatic shock is preserved and considerably increases during the use of the vasopressor in different types of neurovegetative blockade.

[Effect of etiron in combination with fentolamin on systemic hemodynamics]. / Vliianie étirona v kombinatsii s fentolaminom na sistemnuiu gemodinamiku.

Etiron is capable to recover arterial pressure reduced by phentolamine, and to correct, to a certain degree, other parameters of the systemic hemodynamics, that change after administering an alpha-adrenoblocker. The recovery of arterial pressure occurs mainly at the expense of the increased general peripheral resistance, whereas the minute circulatory volume remains almost unchanged.

[Effect of fentolamin and its combination with etiron on microcirculation]. / Vliianie fentolamina i ego sochetaniia s étironom na mikrotsirkuliatsiiu.

It has been shown in experiments on rats anesthetized with thiopental that intravenous injection of phentolamine in a dose of 10 mg/kg enlarges the microvessels of the mesoappendix, pia mater, liver and kidneys and raises the number of functioning capillaries. Administration of etiron after phentolamine stabilized AP and corrects microcirculation. The drug raises the tone of the microvessels when applied locally in a dose of 0.15 ml (1 : 5000) or intravenously in a dose of 20 mg/kg. Etiron largely produces the constriction of the distal vessels of the arterial area of the microvascular bloodstream. The diameter of the microvessels diminished to a greater degree after intravenous injection of etiron in the presence of a alpha-adrenoreceptor blockade as compared to local application. The sensitivity of the microvessels to etiron administered after phentolamine is inversely proportional to their diameter. Combined use of etiron with alpha-adrenoblockers considerably widens the possibilities of drug control of the vascular tone.