Características generales de los tumores de cabeza y cuello. Vías de extensión según las diferentes localizaciones

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[Tonsillar angiofibroma]. / Angiofibroma amigdalar.

We report in this paper a case of a tonsillar angiofibroma, whose histopathological features did not differ from its nasopharyngeal counterpart. In an exhaustive review done we have only found another one reference, in the german literature of such location.

Chemotherapy as a part of each treatment fraction in a twice-a-day hyperfractionated schedule: a new chemoradiotherapy approach for advanced head and neck cancer.

BACKGROUND: Using chemotherapy as a part of each treatment fraction remains unexplored. This study integrates the concomitant administration of carboplatin with hyperfractionated irradiation by optimizing chemopotentiation through carboplatin administration with each irradiation fraction. METHODS: From February 1993 to August 1996, 52 patients with advanced head and neck cancer were treated on a twice-a-day chemoradiotherapy schedule. Each fraction consisted of 115 cGy preceded by 5 mg/m2 of carboplatin. Treatment was given 5 days a week up to total doses of 350 mg/m2 of carboplatin + 8050 cGy in 7 weeks. RESULTS: All (100%) of patients tolerated the treatment (83% as scheduled). Acute and late toxicities were moderate. Rates of 96% complete response (CR) and 4% partial response (PR) were achieved. At 52 months, local control and cause-specific survival rates are 72% and 59%, respectively. Nodal control rate is 95%. CONCLUSION: These results show potential for improvement upon hyperfractionated radiotherapy alone and compare favorably with those of most reported trials.

[Late hereditary degenerative sensorineural hearing loss associated with IgA mesangial glomerulonephritis of probable autosomal dominant heredity]. / Hipoacusia neurosensorial heredodegenerativa tardía, asociada a glomerulonefritis mesangial IgA, de probable herencia autosómica dominante.

We studied four generations of a Canary Islands family presenting a tardive heredodegenerative hearing loss, associated with IgA mesangial glomerulonephritis, of probable autosomal dominant heredity. With respect to the family, we revised Alport's syndrome, for possible transmission associated with X chromosome, as well as heredodegenerative hearing loss associated with renal pathology of autosomic transmission currently described; we differentiate these hearing losses from our case study, and we discuss the pathogeny of the auditive affection in the said hereditary syndromes. Lastly, we stress the autoimmune hypothesis because of the IgA nephropathy association in the family case, and we list the characteristics of the syndrome described.

[Olfactory esthesioneuroblastoma (presentation of 4 cases from the authors' practice)]. / Estesioneuroblastoma olfatorio (presentamos cuatro casos de nuestro servicio).

This is a new case of Esthesioneuroblastoma to joint the other 3 of our Archives. The opportunity is profited in order to make a revision on the subject.