[Effects of mildronate (quaterin) on hemodynamics in spontaneous and artificial heart rhythm in patients with ischemic heart disease]. / Vliianie mildronata (kvaterina) na gemodinamiku pri spontannom i isskustvennom serdechnom ritme u bol'nykh ishemicheskoi bolezn'iu serdtsa.

Central hemodynamic parameters under the effect of mildronate were examined in 62 patients suffering from coronary heart disease, 35 of these with acute myocardial infarction complicated by acute left-ventricular insufficiency and 20 with atherosclerotic cardiosclerosis with chronic cardiac insufficiency. The drug effect was assessed in two groups of patients after a single intravenous injection of 0.5-3 g. In group 1 (n = 53) mildronate effect on central hemodynamic parameters was assessed in spontaneous cardiac rhythm. Variously directed statistically unreliable hemodynamic shifts were revealed, related to heart rhythm changes. In group 2 (n = 9) the drug effect on heart rhythm was eliminated with the use of two-chamber electrocardiostimulation, and various hemodynamic regimens with hypo-, eu-, and hyperkinetic circulation types were artificially created by changing the A-V interval. Mildronate had no effect on the hemodynamics during two-chamber electrocardiostimulation.

[Hemodynamic characteristics during 2-chamber electrostimulation of the heart]. / Osobennosti gemodinamiki pri dvukhkamernoi élektrostimuliatsii serdtsa.

Cardiac output was investigated in coronary patients with temporary (15) and permanent (16) programmed two-chamber electrostimulation of the heart, using different induced atrioventricular interval values. The study was based on integral rheoplethysmography, peripheral volumetric sphygmography, sectoral echocardiography and two-dimensional doppler echocardiography with color code. The adjustment of atrioventricular interval in two-chamber cardiac electrostimulation can modulate cardiac output by means of changing the duration and rate of left-ventricular filling flow, produced by the atrial systole.

[Temporary electrocardiostimulation in paroxysmal arrhythmias in patients with ischemic heart disease]. / Vremennaia elektrokardiostimuliatsiia pri paroksizmal'nykh aritmiiakh u bol'nykh ishemicheskoi bolezn'iu serdtsa.

The efficiency of temporary atrial and ventricular electrocardiostimulation (ECS) used for the control and prevention of recurrent and drug-resistant arrhythmias was studied in 37 patients with coronary heart disease (CHD) and cardiosclerosis, including 21 patients with acute myocardial infarction (MI). The possibility of applying superfrequent ventricular ECS for controlling paroxysms of ventricular tachycardia in acute MI patients, and high efficiency of accelerating-suppressing ECS for the prevention of ventricular tachycardia and ventricular fibrillation paroxysms are demonstrated.

[Effect of nitrates on cardiodynamics in patients with atrioventricular block treated by electrocardiostimulation]. / Vliianie nitratov na kardiodinamiku u bol'nykh s predserdno-zheludochkovoi blokadoi na fone elektrokardiostimuliatsii.

The clinical and hemodynamic effect of nitrates with both their single administration and a prolonged therapy in patients with atrioventricular block related to elecrocardiostimulation has been studied. Nitroglycerin has been found to exercise its action in two phases: first decreasing and then increasing cardiac output. The character of phase I has been ascertained to correlate with the potential development of various complications during the treatment with nitrates. A conclusion has been drawn as to the efficacy of nitrosorbid employment in the multiple modality treatment of chronic cardiac insufficiency in patients with an implanted cardiostimulator.

[Effect of temporary sequential atrioventricular electrocardiostimulation on hemodynamics]. / Vliianie vremennoi posledovatel'noi predserno-zheludochkovoi élektrokardiostimuliatsii na gemodinamiku.

A comparative study of the hemodynamic parameters in 22 patients with coronary heart disease and chronic atrioventricular block, Stage II and III, showed a favourable hemodynamic effect of atrioventricular versus ventricular electrocardiostimulation. Tests with isometric and nitroglycerin loads may be used to identify patients in the most urgent need for atrioventricular electrocardiostimulation.

[Clinico-electrophysiologic study of the anti-arrhythmic action of trimecaine]. / Kliniko-élektrofiziologicheskoe izuchenie antiaritmicheskogo deistviia trimekaina.

The antiarrhythmic activity of trimecaine hydrochloride administered orally and intramuscularly was studied in 58 patients with coronary heart disease accompanied by ventricular and supraventricular rhythm disorders. In 73.9% of the cases the drug exhibited antiarrhythmic action which was reflected in a longer period of the recovery of sinus node function, inhibited conduction in the atrioventricular node and a decreased time of intraatrial conduction. Side effects were observed in 17.3% of the cases mostly with the oral drug; they tended to abate spontaneously 2-4 h after trimecaine hydrochloride withdrawal.

[Evaluation of the state of cardiodynamics in patients with artificial pacemaker]. / Otsenka sostoianiia kardiodinamiki u patsientov s iskusstvennym voditelem ritma.

Cardiodynamic parameters were studied in 23 patients with an implanted cardiostimulator both at rest and in conditions of an isometric exercise test. Three types of blood circulation were identified, namely eu-, hypo-, and hyperkinetic. The individual types of circulation were shown to be correlated with the severity of the clinical course of the underlying disease. The isometric exercise test allowed the researchers to differentiate between adequate and inadequate responses of hemodynamics in patients with an artificial pacemaker. It is concluded advisable to investigate the hemodynamic state of patients with an implanted artificial pacemaker so as to decide on any corrective measures that may be needed.

[Experience in using nitroglycerin in the acute period of myocardial infarct]. / Opyt primeneniia nitroglitserina v ostrom periode infarkta miokarda.

To treat the left ventricular insufficiency, complicating myocardial infarction, and to limit the area of the ischemic damage of myocardium the authors used nitroglycerin solution. It is established that the nitroglycerin injection stops effectively the acute left ventricular insufficiency in myocardial infarction. Results of investigations show the decrease of the ischemic zone of the damaged myocardium in the acute period of infarction under the influence of nitroglycerin. It is concluded that intravenous drop administration of nitroglycerin is rational, under thorough control of the arterial pressure, the central venous pressure and intracardiac haemodynamics.