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J Med Chem ; 59(8): 4019-25, 2016 04 28.
Artigo em Inglês | MEDLINE | ID: mdl-27010220

RESUMO

Caveolin-1 is a target for academic and pharmaceutical research due to its many cellular roles and associated diseases. We report peptide WL47 (1), a small, high-affinity, selective disrupter of caveolin-1 oligomers. Developed and optimized through screening and analysis of synthetic peptide libraries, ligand 1 has 7500-fold improved affinity compared to its T20 parent ligand and an 80% decrease in sequence length. Ligand 1 will permit targeted study of caveolin-1 function.


Assuntos
Biopolímeros/metabolismo , Caveolina 1/metabolismo , Ligantes
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