RESUMO
The paper presents the results of a 6-year investigation of hemopoiesis of dogs which were exposed to double irradiations (with a 1.5-month interval) with protons at a dose of 350 rad when different parts of the body (head, chest, abdomen, pelvis) were shielded. Throughout the entire period the dogs showed moderate leucopenia and by the end of the investigation insignificant anemia. The dogs irradiated with shielded abdomen displayed disturbances in bone marrow hemopoiesis, whereas other dogs exhibited relative, although transient, normalization. All the dogs showed a significant decrease of erythropoiesis and a relative stability of leucopoiesis as well as a significant elevation of the number of reticulocytes, monocytes and plasmocytes 5.5 year after irradiation.
Assuntos
Medula Óssea/efeitos da radiação , Hematopoese/efeitos da radiação , Prótons , Proteção Radiológica , Doença Aguda , Animais , Contagem de Células Sanguíneas , Cães , Relação Dose-Resposta à Radiação , Doses de Radiação , Lesões Experimentais por Radiação/fisiopatologia , Fatores de TempoRESUMO
The dependece of radiation injury of piglets on the area of irradiated body surface (v 40 kv, Eeff 17 key, 1 10 mA per tube, additional filter 0.1 mm A1, delta 1/2 0.08 mm A1, source--skin distance 30 cm, R 504 r/min, radiattion dose 200 r) was studied. The biological effect was evaluated with respect to the clinical, hematological and biochemical changes in the animal body. The data were obtained that indicated burn disease in the irradiated piglets, severity of which increased with an increased with an increase of the area of irradiated skin surface.