[Fatty-acid composition of plasma and erythrocyte lipids in patients with metabolic syndrome].

The paper gives the results of a comparative assessment of gas chromatographic analysis of plasma and peripheral erythrocyte lipids in patients with the metabolic syndrome (MS). The established changes in the fatty-acid composition of erythrocyte and plasma lipids in patients with MS substantiate the prospects for using this technique in the diagnosis of lipid metabolic disturbances.

[Characteristics of the fatty acid spectra of low density lipoproteins in patients after myocardial infarction]. / Osobennosti zhirno-kislotnykh spektrov lipidov lipoproteinov nizkoi plotnosti u bol'nykh, perenesshikh infarkt miokarda.

The results of gas-chromatography assay of the fatty-acid composition of lipids of low-density lipoproteins contained in blood serum of patients after myocardium infarction are described in the paper. The obtained data can be used in clinical practice for substantiating a therapeutic approach with the aim of enhancing the treatment efficiency.

[The role of free-radical processes in determining immune disorders in unstable angina and the principles for their correction]. / Rol' svobodnoradikal'nykh protsessov v determinatsii immunnykh narushenii pri nestabil'noi stenokardii i printsipy ikh korrektsii.

The interaction was studied of homeostatic lipids of the membrane components in the blood plasma as was the correction thereof and condition of the bodily immune processes in patients with unstable angina pectoris (UAP). A total of fifty UAP patients were treated with lipid. Utilization of the lipid modulus was found out to have a striking immunoregulation effect. Activation of the phagocytic link of the immune response was noted to be on the decrease, the disbalance of the regulatory lymphocyte subpopulations getting less, which facts result in lowering of the autoantibodies production, normalization of blood free radical processes and pronounced clinical effect in the above patient population.

[The role of free radical processes in the development of autosensitization in ischemic heart disease]. / Rol' svobodnoradikal'nykh protsessov v razvitii autosensibilizatsii pri ishemicheskoi bolezni serdtsa.

Derangement in freeradical processes (FRP) and lipid metabolism is known to occur in ischemic heart disease. Since autoimmune component appear to play an important role in the pathogenesis of IHD, the contributers to the article studied the state of freeradical processes in IHD patients during development of autosensibilization. A total of 42 patients with unstable angina and 8 essentially healthy subjects were examined. The blood level of FRP, antioxidant protection were determined using chemiluminometry technique. The blood serum content of free cholesterol and phospholipid fatty acid composition were evaluated by gas-liquid chromatography, the T- and B-lymphocyte functional status by fluorescent probing with acridine orange. The level of autoantibodies was determined as recommended by Boiden. The lymphocyte circulating population functional activity was found to be related to the state of FRP, antioxidant protection and the blood serum lipidic complex composition.

[Effectiveness of heparin in patients with acute myocardial infarction]. / Ob effektivnosti geparina u bol'nykh ostrym infarktom miokarda.

Clinical pattern and complications of the disease were studied in 62 heparin-treated patients with large-focal myocardial infarction as compared to a control group of 59 patients treated with a polarizing mixture of glucose, insulin, potassium, analgetics and tranquilizers. The changes of the necrotic area and lesion were assessed on the basis of precardiac charting. The results obtained were correlated to the data on central hemodynamics, heart contractility and pumping function, gaseous exchange and acid-base balance. Heparin-treated patients showed a smaller rate of fatal outcomes, although primary ventricular fibrillation and heart failure prevailed in the mortality pattern in both groups. Heparin treatment improved central hemodynamics, contractility and pumping function of the heart, and gaseous exchange, while prestress decreased simultaneously, which is the optimum effect for patients with acute myocardial infarction. Precardiac charting data showed heparin treatment to be associated with a more rapid reduction in the depth of the ischemic lesion. The advantages of continuous intravenous heparin infusion are demonstrated.