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1.
Infect Control Hosp Epidemiol ; 35(1): 10-5, 2014 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-24334792

RESUMO

OBJECTIVE: We determined the percentage of healthcare workers' (HCWs') hands contaminated with Clostridium difficile spores after caring for patients with C. difficile infection (CDI) and risk factors associated with contamination. DESIGN: Prospective study. SETTING: A French university hospital. METHODS: We compared the hand contamination rate among HCWs caring for patients with CDI (exposed group; n = 66) with that among an unexposed group (n = 44). Spores of C. difficile were recovered from the hands of HCWs after rubbing their fingers and palms in alcohol shortly after patient care. Associations between hand contamination and HCW category, type (patient or environment), and risk level (high or low risk) of HCW contacts and their respective duration as well as use of gloves were analyzed by bivariate and multivariate analysis. RESULTS: C. difficile spores were detected on 24% of HCWs' hands in the exposed group and on 0% in the unexposed group (P < .001). In the exposed group, logistic regression, which adjusted for high-risk contact (ie, exposure to fecal soiling), contact with the environment, and contact with or without use of gloves, revealed that high-risk contact (adjusted odds ratio [aOR] per 1 contact increment, 2.78; 95% confidence interval [CI], 1.42-5.45; P = .003) and at least 1 contact without use of gloves (aOR, 6.26; 95% CI, 1.27-30.78; P = .02) were independently associated with HCW hand contamination by C. difficile spores. CONCLUSIONS: Nearly one-quarter of HCWs have hands contaminated with C. difficile spores after routine care of patients with CDI. Hand contamination is positively associated with exposure to fecal soiling and lack of glove use.


Assuntos
Clostridioides difficile/isolamento & purificação , Enterocolite Pseudomembranosa/transmissão , Mãos/microbiologia , Transmissão de Doença Infecciosa do Paciente para o Profissional , Recursos Humanos em Hospital , Infecção Hospitalar/transmissão , Enterocolite Pseudomembranosa/terapia , Fezes/microbiologia , França , Luvas Protetoras/microbiologia , Hospitais Universitários , Humanos , Estudos Prospectivos , Fatores de Risco , Esporos Bacterianos/isolamento & purificação , Fatores de Tempo
2.
Clin Microbiol Infect ; 17(2): 292-9, 2011 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-20167008

RESUMO

Incubation time affects the clinical features and outcome of many nosocomial infections. However, its role in the setting of post-sternotomy mediastinitis (PSM) has not been specifically studied. The present study aimed to evaluate the impact of time to onset of PSM on the clinical presentation and outcomes of patients. Hospital records of 197 patients who developed PSM over a 10-year period and were treated by closed drainage using Redon catheters were reviewed retrospectively. Follow-up was complete for all included patients (median of 19 months); 98 patients developed early-onset PSM (time from initial operation to PSM <14 days) and 99 patients had late-onset PSM (≥14 days). Patients with late-onset PSM had a higher rate of internal thoracic artery harvest and mediastinal re-exploration after initial operation. Patients with early-onset PSM presented more frequently with septic shock. Microbiological findings differed between early- and late-onset PSM by a higher incidence of Enterococcus species in the former and of Staphylococcus aureus in the latter. Overall mortality reached 34% (n = 66). Rates of superinfection, treatment failure, mediastinitis-related death, mortality at 1 year and overall mortality were all significantly higher in patients with early-onset PSM. Multiple regression procedures identified early-onset PSM as a significant and independent risk factor for both 1-year (OR 2.40; 95% CI 1.12-5.11) and overall (OR 2.11; 95% 1.26-3.53) mortality. In conclusion, the results obtained in the present study support the distinction between early- and late-onset PSM with different clinical and pathophysiological features. Early-onset PSM is associated with a significantly higher morbidity and mortality compared to late-onset PSM.


Assuntos
Infecções Bacterianas/patologia , Período de Incubação de Doenças Infecciosas , Mediastinite/patologia , Esternotomia/efeitos adversos , Infecção da Ferida Cirúrgica/patologia , Idoso , Idoso de 80 Anos ou mais , Bactérias/isolamento & purificação , Infecções Bacterianas/microbiologia , Feminino , Humanos , Masculino , Mediastinite/microbiologia , Pessoa de Meia-Idade , Prognóstico , Estudos Retrospectivos , Infecção da Ferida Cirúrgica/microbiologia
3.
Clin Microbiol Infect ; 17(3): 425-31, 2011 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-20384710

RESUMO

The full identification and susceptibility profile of staphylococci from positive blood cultures (BCs) generally takes 24-48 h using phenotypic methods. The aim of this prospective study was to evaluate the clinical impact of a real-time PCR strategy for rapid identification of staphylococci and determination of methicillin resistance directly from positive BCs. During a 12-month period, 250 episodes of positive BCs with organism morphology resembling staphylococci were enrolled. Two strategies were compared: conventional (n = 128) using standard phenotypic methods or rapid (n = 122) using a real-time PCR assay that is able to detect specific genes of Staphylococcus aureus (nuc and sa442) and the encoding gene for methicillin resistance (mecA). Overall, 97 episodes (39%) were clinical-significant bloodstream infections. The prevalence of methicillin resistance of S. aureus was 24%. A favorable outcome (defined as clinical cure with resolution of signs and no evidence of recurrence or relapse at 12 weeks follow-up) was observed in similar proportions of episodes with (58%) or without (60%) PCR testing (p 0.8). In multivariate analyses, age and infection due to methicillin-susceptible S. aureus (adjusted OR 0.96, 95% CI 0.93-0.99; and adjusted OR 3.11, 95% CI 1.12-8.65, respectively) were the unique factors independently associated with a favorable outcome. Among the 153 episodes of contaminated BCs, similar proportions received unjustified antibiotic therapy (PCR strategy: 17%, conventional testing: 10%; p 0.33). In a setting with a moderate level of methicillin-resistant S. aureus and relatively high contamination of BCs, real-time PCR testing was not beneficial compared to conventional methods.


Assuntos
Resistência a Meticilina/genética , Staphylococcus aureus Resistente à Meticilina/genética , Infecções Estafilocócicas/sangue , Idoso , Antifúngicos/uso terapêutico , Proteínas de Bactérias/genética , Feminino , Humanos , Masculino , Staphylococcus aureus Resistente à Meticilina/classificação , Pessoa de Meia-Idade , Técnicas de Diagnóstico Molecular , Proteínas de Ligação às Penicilinas , Reação em Cadeia da Polimerase , Recidiva , Infecções Estafilocócicas/tratamento farmacológico , Infecções Estafilocócicas/microbiologia , Infecções Estafilocócicas/mortalidade
4.
Infect Control Hosp Epidemiol ; 30(6): 507-14, 2009 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-19379098

RESUMO

OBJECTIVE: To compare a hydrogen peroxide dry-mist system and a 0.5% hypochlorite solution with respect to their ability to disinfect Clostridium difficile-contaminated surfaces in vitro and in situ. DESIGN: Prospective, randomized, before-after trial. SETTING: Two French hospitals affected by C. difficile. INTERVENTION: In situ efficacy of disinfectants was assessed in rooms that had housed patients with C. difficile infection. A prospective study was performed at 2 hospitals that involved randomization of disinfection processes. When a patient with C. difficile infection was discharged, environmental contamination in the patient's room was evaluated before and after disinfection. Environmental surfaces were sampled for C. difficile by use of moistened swabs; swab samples were cultured on selective plates and in broth. Both disinfectants were tested in vitro with a spore-carrier test; in this test, 2 types of material, vinyl polychloride (representative of the room's floor) and laminate (representative of the room's furniture), were experimentally contaminated with spores from 3 C. difficile strains, including the epidemic clone ribotype 027-North American pulsed-field gel electrophoresis type 1. RESULTS: There were 748 surface samples collected (360 from rooms treated with hydrogen peroxide and 388 from rooms treated with hypochlorite). Before disinfection, 46 (24%) of 194 samples obtained in the rooms randomized to hypochlorite treatment and 34 (19%) of 180 samples obtained in the rooms randomized to hydrogen peroxide treatment showed environmental contamination. After disinfection, 23 (12%) of 194 samples from hypochlorite-treated rooms and 4 (2%) of 180 samples from hydrogen peroxide treated rooms showed environmental contamination, a decrease in contamination of 50% after hypochlorite decontamination and 91% after hydrogen peroxide decontamination (P < .005). The in vitro activity of 0.5% hypochlorite was time dependent. The mean (+/-SD) reduction in initial log(10) bacterial count was 4.32 +/- 0.35 log(10) colony-forming units after 10 minutes of exposure to hypochlorite and 4.18 +/- 0.8 log(10) colony-forming units after 1 cycle of hydrogen peroxide decontamination. CONCLUSION: In situ experiments indicate that the hydrogen peroxide dry-mist disinfection system is significantly more effective than 0.5% sodium hypochlorite solution at eradicating C. difficile spores and might represent a new alternative for disinfecting the rooms of patients with C. difficile infection.


Assuntos
Clostridioides difficile/efeitos dos fármacos , Desinfetantes/farmacologia , Desinfecção/métodos , Enterocolite Pseudomembranosa/prevenção & controle , Peróxido de Hidrogênio/farmacologia , Hipoclorito de Sódio/farmacologia , Esporos Bacterianos/efeitos dos fármacos , Clostridioides difficile/fisiologia , Infecção Hospitalar/microbiologia , Infecção Hospitalar/prevenção & controle , Desinfetantes/administração & dosagem , Enterocolite Pseudomembranosa/microbiologia , Microbiologia Ambiental , França , Hospitais Universitários , Humanos , Peróxido de Hidrogênio/administração & dosagem , Controle de Infecções/métodos , Quartos de Pacientes , Hipoclorito de Sódio/administração & dosagem , Resultado do Tratamento , Volatilização
5.
Infect Control Hosp Epidemiol ; 27(8): 847-54, 2006 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-16874646

RESUMO

OBJECTIVE: Urinary tract infections are the leading nosocomial urologic infections and may be a cause of added morbidity and costs, and sometimes sepsis. The aim of this study was to design a predictive score for these complications after prostate surgery. DESIGN: Multicenter prospective survey. SETTING: Eleven French urology centers. PATIENTS: All patients undergoing transurethral resection of prostate (TURP) during a 3-month period. RESULTS: The overall incidence of postoperative bacteriuria was 25.0% (95% confidence interval, 17.7%-29.5%). Almost all patients (95.7%) received antibiotic prophylaxis. A predictive postoperative bacteriuria score (POBS), with a 6-point scale of 0 to 5, was constructed on the basis of independent risk factors identified in multivariate analysis of a test sample of patients (n=135) and tested in a validation sample (n=73). Significantly more infections occurred in patients with a POBS of 2 or higher (87 [8%] vs 48 [50%]; P<.0001). With the test sample, this yielded a sensitivity of 77%, a specificity of 77%, a positive predictive value of 50%, a negative predictive value of 92%, and a global accuracy of 77%. CONCLUSIONS: POBS could be used to distinguish patients at risk of developing infection after TURP. This information might be useful for implementing selective prevention measures or for adjustment for differences in nosocomial infection rates when comparing data between urology centers.


Assuntos
Infecções Bacterianas/diagnóstico , Bacteriúria/etiologia , Infecção Hospitalar/fisiopatologia , Complicações Pós-Operatórias/diagnóstico , Ressecção Transuretral da Próstata/efeitos adversos , Idoso , Idoso de 80 Anos ou mais , Técnicas Bacteriológicas , Bacteriúria/diagnóstico , Bacteriúria/epidemiologia , Infecção Hospitalar/etiologia , Infecção Hospitalar/prevenção & controle , Coleta de Dados , Humanos , Masculino , Estudos Prospectivos , Fatores de Risco
6.
J Hosp Infect ; 57(2): 162-9, 2004 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-15183248

RESUMO

Improvement in hand hygiene compliance is important for reducing cross-infection by micro-organisms. The objective of this prospective observational study was to measure how the improper use of gloves limits compliance to hand hygiene and exposes patient's to infection. The study was conducted in five wards (three intensive care units and two medical wards) in a French university hospital. Staff-patient and staff-environment contacts were observed in 120 healthcare workers caring for patients colonized or infected with pathogenic bacteria. Hand hygiene was not undertaken due to improper gloving in 64.4% (95%CI, 64.1% to 65.1%) of instances. Possible microbial transmission might have occurred in 18.3% (95%CI, 17.8% to 18.8%) of all contacts because used gloves were not removed before performing care activities that necessitated strict aseptic precautions. Failure to change or remove contaminated gloves was a major component in the poor compliance with hand hygiene and carried a high-risk of microbial transmission. Improving hand hygiene compliance will require changing healthcare workers behaviour towards glove use.


Assuntos
Infecção Hospitalar/prevenção & controle , Luvas Protetoras/microbiologia , Fidelidade a Diretrizes , Desinfecção das Mãos/normas , Unidades Hospitalares , Higiene/normas , Transmissão de Doença Infecciosa do Profissional para o Paciente/prevenção & controle , Anti-Infecciosos Locais , Contagem de Colônia Microbiana , Infecção Hospitalar/microbiologia , Infecção Hospitalar/transmissão , França , Luvas Protetoras/estatística & dados numéricos , Hospitais Universitários , Humanos , Resistência a Meticilina , Assistentes de Enfermagem/normas , Recursos Humanos de Enfermagem Hospitalar/normas , Estudos Prospectivos , Medição de Risco , Staphylococcus aureus/efeitos dos fármacos , Staphylococcus aureus/isolamento & purificação
7.
Eur Respir J Suppl ; 42: 72s-76s, 2003 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-12946004

RESUMO

Patients with acute respiratory failure are predisposed to acquire nosocomial infection primarily because they may need ventilatory support, usually invasive mechanical ventilation. The presence of an endotracheal tube impairs natural defences of the respiratory tract and favours airways colonisation and lung infection. Cross transmission of microorganisms may also occur via contaminated hands of healthcare workers that manipulate invasive devices. Thus, avoiding the endotracheal tube and increasing hand hygiene compliance are major measures to prevent ventilator-associated pneumonia. The use of noninvasive ventilation has been shown to reduce the incidence of nosocomial infections and should be used whenever possible. Using hand rubbing with waterless alcohol-based products evidenced higher efficacy to reduce hand contamination as compared to conventional hand washing with soap. Due to its rapid activity and ease of access, hand rubbing constitutes a promising avenue for improving hand hygiene compliance and thus reducing cross infection.


Assuntos
Infecção Hospitalar/prevenção & controle , Intubação Intratraqueal/efeitos adversos , Pneumonia/prevenção & controle , Prevenção Primária/métodos , Respiração Artificial/efeitos adversos , Insuficiência Respiratória/terapia , Doença Aguda , Infecção Hospitalar/etiologia , Deambulação Precoce , Contaminação de Equipamentos/prevenção & controle , Humanos , Umidade , Pneumonia/etiologia , Fatores de Risco
8.
J Hosp Infect ; 48 Suppl A: S55-7, 2001 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-11759028

RESUMO

The baseline compliance with handwashing in a French university hospital was as low as the compliance rates reported in other countries, i.e., less than 50%. By introducing the use of hand-rubbing with an alcoholic solution, as a substitution method for both handwashing with soap and handwashing with an antiseptic agent, we significantly improved hand-cleansing compliance. Despite these encouraging results, mainly due to the accessibility of these non-aqueous products, three major obstacles remain before a wide acceptance by healthcare workers: distrust in terms of efficacy, distrust in terms of skin tolerance and lack of knowledge on hand-cleansing indications.


Assuntos
Anti-Infecciosos Locais/farmacologia , Atitude do Pessoal de Saúde , Etanol/farmacologia , Fidelidade a Diretrizes/estatística & dados numéricos , Guias como Assunto , Desinfecção das Mãos/métodos , Desinfecção das Mãos/normas , Hospitais Universitários/normas , Capacitação em Serviço/organização & administração , Recursos Humanos em Hospital/educação , Recursos Humanos em Hospital/psicologia , França , Conhecimentos, Atitudes e Prática em Saúde , Humanos , Avaliação das Necessidades , Avaliação de Programas e Projetos de Saúde , Sabões , Inquéritos e Questionários , Gestão da Qualidade Total
9.
JAMA ; 284(18): 2361-7, 2000 Nov 08.
Artigo em Inglês | MEDLINE | ID: mdl-11066187

RESUMO

CONTEXT: Invasive life-support techniques are a major risk factor for nosocomial infection. Noninvasive ventilation (NIV) can be used to avoid endotracheal intubation and may reduce morbidity among patients in intensive care units (ICUs). OBJECTIVE: To determine whether the use of NIV is associated with decreased risk of nosocomial infections and improved survival in everyday clinical practice among patients with acute exacerbation of chronic obstructive pulmonary disease (COPD) or hypercapnic cardiogenic pulmonary edema (CPE). DESIGN AND SETTING: Matched case-control study conducted in the medical ICU of a French university hospital from January 1996 through March 1998. PATIENTS: Fifty patients with acute exacerbation of COPD or severe CPE who were treated with NIV for at least 2 hours and 50 patients treated with mechanical ventilation between 1993 and 1998 (controls), matched on diagnosis, Simplified Acute Physiology Score II, Logistic Organ Dysfunction score, age, and no contraindication to NIV. MAIN OUTCOME MEASURES: Rates of nosocomial infections, antibiotic use, lengths of ventilatory support and of ICU stay, ICU mortality, compared between cases and controls. RESULTS: Rates of nosocomial infections and of nosocomial pneumonia were significantly lower in patients who received NIV than those treated with mechanical ventilation (18% vs 60% and 8% vs 22%; P<.001 and P =.04, respectively). Similarly, the daily risk of acquiring an infection (19 vs 39 episodes per 1000 patient-days; P =.05), proportion of patients receiving antibiotics for nosocomial infection (8% vs 26%; P =.01), mean (SD) duration of ventilation (6 [6] vs 10 [12] days; P =.01), mean (SD) length of ICU stay (9 [7] vs 15 [14] days; P =.02), and crude mortality (4% vs 26%; P =.002) were all lower among patients who received NIV than those treated with mechanical ventilation. CONCLUSIONS: Use of NIV instead of mechanical ventilation is associated with a lower risk of nosocomial infections, less antibiotic use, shorter length of ICU stay, and lower mortality. JAMA. 2000;284:2361-2367.


Assuntos
Infecção Hospitalar/etiologia , Pneumopatias Obstrutivas/terapia , Respiração com Pressão Positiva , Edema Pulmonar/terapia , APACHE , Idoso , Antibacterianos/uso terapêutico , Estudos de Casos e Controles , Estado Terminal , Infecção Hospitalar/complicações , Infecção Hospitalar/epidemiologia , Feminino , Humanos , Unidades de Terapia Intensiva , Tempo de Internação , Pneumopatias Obstrutivas/complicações , Pneumopatias Obstrutivas/mortalidade , Masculino , Máscaras , Pessoa de Meia-Idade , Respiração com Pressão Positiva/efeitos adversos , Respiração com Pressão Positiva/métodos , Edema Pulmonar/complicações , Edema Pulmonar/mortalidade , Estudos Retrospectivos , Risco , Análise de Sobrevida
10.
Infect Control Hosp Epidemiol ; 21(9): 583-7, 2000 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-11001261

RESUMO

OBJECTIVE: To compare two strategies for screening methicillin-resistant Staphylococcus aureus (MRSA) carriers in a high-risk dermatology ward: systematic screening of all admitted patients versus selective screening of patients at risk. DESIGN: The two strategies were applied prospectively during two consecutive periods. In period A (8.5 months), only patients transferred from other wards, or with a history of prior hospitalization, or presenting chronic wounds or disease with denuded skin were considered at high risk of MRSA carriage and sampled. In period B (7.5 months), all admitted patients were systematically screened. End-points were the number of patients having a MRSA-positive screening sample on admission during period B and having none of the risk factors used in period A, the rate of imported MRSA cases, and the rate of acquired cases. SETTING: A 1,032-bed university hospital with a 19-bed inpatient dermatology ward, a referral center for toxic epidermal necrolysis and severe extensive dermatoses. PATIENTS: The study included 729 dermatology inpatients (370 in period A and 359 in period B). RESULTS: During period A, screening samples were obtained on admission for 30% of patients (77% of the patients at risk) and identified 25 MRSA carriers. During period B, 90.5% of admitted patients were screened, and 26 MRSA carriers were detected on admission; all of these patients belonged to at least one predefined category at risk for carriage. Overall rates of imported and acquired cases were similar between the two periods (6.8% vs 7.5%, and 2.9% vs 2.4%, respectively). CONCLUSIONS: A screening strategy targeted to patients at risk of harboring MRSA has similar sensitivity and is more cost-effective than a strategy of systematic screening to identify MRSA carriers on admission.


Assuntos
Infecção Hospitalar/diagnóstico , Resistência a Meticilina , Infecções Estafilocócicas/diagnóstico , Staphylococcus aureus/efeitos dos fármacos , Dermatologia , Hospitais com mais de 500 Leitos , Humanos , Programas de Rastreamento , Testes de Sensibilidade Microbiana , Admissão do Paciente , Fatores de Risco , Dermatopatias/microbiologia , Infecções Estafilocócicas/tratamento farmacológico , Staphylococcus aureus/patogenicidade , Ferimentos e Lesões/microbiologia
11.
J Antimicrob Chemother ; 46(3): 501-8, 2000 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-10980183

RESUMO

We evaluated the appropriateness of use of restricted antimicrobial agents in the context of a newly implemented order form and delivery system for restricted antimicrobial agents, using sequential prospective audits of prescriptions. Four antimicrobial agents were selected: glycopeptides (61 prescriptions), ciprofloxacin (42), piperacillin-tazobactam (42) and imipenem- cilastatin (47). The justification and adequacy of the antibiotic or combination used, reassessment of therapy and duration of treatment were appraised with reference to the clinical situation and hospital's guidelines. Of the 192 prescriptions, 30 (16%) were empirical therapy, 95 (49%) empirical and secondarily documented and 67 (35%) initially documented therapy. Overall, 73% of prescriptions conformed to guidelines, but the adequacy varied from 93% for vancomycin to only 38% for ciprofloxacin. Of 83/157 initially inadequate prescriptions, 42 (51%) were switched according to guidelines, but only 14% of ciprofloxacin prescriptions were adapted later. An intervention audit with counselling on ciprofloxacin usage increased this rate to 75%. Although implementation of the guidelines resulted in a marked reduction in overall antimicrobial costs, inappropriate antibiotic usage may persist for some drugs despite restricted access. These results emphasize the need for combined interventions using education and expert counselling, targeted to classes of antibiotic for which inappropriate usage is most common.


Assuntos
Antibacterianos/uso terapêutico , Revisão de Uso de Medicamentos , Infecções/tratamento farmacológico , Antibacterianos/economia , Empirismo , Hospitais , Humanos , Auditoria Médica , Padrões de Prática Médica
12.
Am J Respir Crit Care Med ; 162(1): 197-202, 2000 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-10903241

RESUMO

Poor hemodynamic tolerance of intermittent hemodialysis (IHD) is a common problem for patients in an intensive care unit (ICU). New dialysis strategies have been adapted to chronic hemodialysis patients with cardiovascular insufficiency. To improve hemodynamic tolerance of IHD, specific guidelines were progressively implemented into practice through the year 1996 in our 26-bed medical ICU. To evaluate the efficiency of these guidelines we retrospectively compared all IHD performed during the years before (1995) and after (1997) implementation of these recommendations. Forty-five patients underwent 248 IHD sessions in 1995 and 76 patients underwent 289 IHD sessions in 1997. The two populations were similar for age, sex, chronic hemodialysis (26% versus 17%), and secondary acute renal failure. In 1997, patients were more severely ill with a higher SAPS II (50 +/- 17 versus 59 +/- 24; p = 0.036), and more patients required epinephrine or norepinephrine infusion before dialysis sessions (16% versus 34%; p < 0.0001). The compliance to guidelines was high, inducing a significant change in IHD modalities. As a result, hemodynamic tolerance was significantly better in 1997, with less systolic blood pressure drop at onset (33% versus 21%, p = 0. 002) and during the sessions (68% versus 56%, p = 0.002). IHD with hypotensive episode or need for therapeutic interventions were less frequent in 1997 (71% versus 61%, p = 0.015). The ICU mortality was similar (53.3% in 1995 versus 47.3% in 1997; p = 0.52) but death rate in 1997, but not in 1995, was significantly less than predicted from SAPS II (47.3% versus 65.6%; p = 0.02). Length of ICU stay was also reduced for survivors in 1997 (p = 0.04). Implementation of practice guidelines for intermittent hemodialysis in ICU patients lessens hemodynamic instability and may improve outcome.


Assuntos
Estado Terminal/terapia , Hemodinâmica , Diálise Renal , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Guias de Prática Clínica como Assunto
14.
Am J Respir Crit Care Med ; 161(5): 1597-601, 2000 May.
Artigo em Inglês | MEDLINE | ID: mdl-10806161

RESUMO

Right heart catheterization (RHC) has been suspected of increasing mortality. The acute respiratory distress syndrome (ARDS) is a frequent reason for RHC. We designed a retrospective cohort study of 119 consecutive ARDS patients admitted to two medical intensive care units of tertiary care hospitals in which two different approaches are used for hemodynamic monitoring: RHC on demand (Henri Mondor Hospital [HM]) and no use of RHC (Ambroise Paré Hospital [AP]). The study tried to identify risk factors for death, and to assess the influence of RHC, with adjustment for the intensity of hemodynamic support as a confounding factor, using 98 patients in whom the delay between onset of ARDS, use of vasopressors, and RHC did not exceed 48 h. Several variables, including septic shock, cause of ARDS, Simplified Acute Physiology Score (SAPS) II, use of epinephrine/norepinephrine, and presence of RHC were entered into a logistic regression model to evaluate their independent prognostic roles. Mortality was different at HM and AP (36 of 55 patients [65.5%] versus 16 of 43 patients [37.2%], p < 0.005), and 29 of the 35 RHC-monitored patients died (82.8%), as compared with 23 of 63 patients (36.5%) treated without RHC (p < 0.0001). However, administration of epinephrine/norepinephrine and a nonpulmonary cause of ARDS were each independently associated with death. It is only when administration of vasopressors was omitted from the model that RHC, septic shock, and SAPS II became independent predictors of mortality. These results suggest that: (1) the use of vasopressors, but not of RHC, represents an important prognostic factor; and (2) not taking into account the use of these drugs may be misleading when assessing the influence of RHC on outcome.


Assuntos
Cateterismo Cardíaco/efeitos adversos , Monitorização Fisiológica/efeitos adversos , Síndrome do Desconforto Respiratório/mortalidade , Adulto , Feminino , Mortalidade Hospitalar , Humanos , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Prognóstico , Síndrome do Desconforto Respiratório/fisiopatologia , Síndrome do Desconforto Respiratório/terapia , Estudos Retrospectivos , Fatores de Risco , Vasoconstritores/administração & dosagem
17.
Proc AMIA Symp ; : 696-700, 1999.
Artigo em Inglês | MEDLINE | ID: mdl-10566449

RESUMO

To optimize the surveillance and control of infections at our hospital, we have developed a clinical information system (CIS) linked to a server providing three kinds of patient-oriented data reports: 1/an automated alert for multiresistant bacteria from a data-driven mechanism; 2/the relevant data for surveillance of hospital-acquired infections; 3/some clinical and educational data for antibiotic prescribing. The new CIS is a Web-based one and now integrated to the Hospital Information System (HIS). In a close collaboration with the experts, we have, first, specified the relevant information for each report. Then, we have linked the system to those HIS DBs containing this information. Finally we have developed a well-secured intranet Web site, on which the concerned practitioners can instantaneously review the latest alerts and/or the summarized/detailed reports. The preliminary results shows that the system is reliable in medical practice and the response time is satisfying.


Assuntos
Infecção Hospitalar/epidemiologia , Resistência a Múltiplos Medicamentos , Sistemas de Informação Hospitalar , Internet , Vigilância da População/métodos , Algoritmos , Sistemas de Informação Hospitalar/organização & administração , Humanos , Sistemas Computadorizados de Registros Médicos , Integração de Sistemas
19.
Clin Infect Dis ; 27(3): 543-50, 1998 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-9770155

RESUMO

Screening for methicillin-resistant Staphylococcus aureus (MRSA) carriage in patients at risk was evaluated as part of a control program in a 26-bed medical intensive care unit (ICU) of a university hospital with a high level of endemic MRSA. Control measures included isolation and barrier precautions, skin decolonization with chlorhexidine of patients from whom MRSA was recovered, and mupirocin treatment of nasal carriers of MRSA. Of 3,686 patients admitted during a 4-year period, 44% were screened, which occurred during admission for 38%; MRSA was recovered from 293 patients (8%). There were 150 imported cases and 143 ICU-acquired cases, of which 51% and 45%, respectively, were first identified through screening. Nasal swab cultures identified 84% of MRSA carriers. The incidence of all ICU-acquired cases and of acquired colonization or infection decreased from 5.8% and 5.6% to 2.6% and 1.4% (P = .002 and P < .001), respectively, whereas that of imported cases remained unchanged (range, 3.8% to 4.3%; P = .8). Selective screening for nasal carriage during admission to high-risk areas may contribute to identification of a substantial proportion of cases of MRSA and to early implementation of effective control measures.


Assuntos
Portador Sadio/diagnóstico , Infecção Hospitalar/diagnóstico , Doenças Endêmicas , Programas de Rastreamento , Resistência a Meticilina , Infecções Estafilocócicas/diagnóstico , Infecção Hospitalar/epidemiologia , Infecção Hospitalar/microbiologia , Infecção Hospitalar/prevenção & controle , Doenças Endêmicas/prevenção & controle , Humanos , Unidades de Terapia Intensiva , Pessoa de Meia-Idade , Infecções Estafilocócicas/epidemiologia , Infecções Estafilocócicas/mortalidade , Infecções Estafilocócicas/prevenção & controle , Staphylococcus aureus/isolamento & purificação
20.
Am J Respir Crit Care Med ; 157(4 Pt 1): 1151-8, 1998 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-9563733

RESUMO

Intensive-care-unit (ICU) patients are at risk for both acquiring nosocomial infection and dying, and require a high level of therapy whether infection occurs or not. The objective of the present study was to precisely define the interrelationships between underlying disease, severity of illness, therapeutic activity, and nosocomial infections in ICU patients, and their respective influences on these patients' outcome. In a 10-bed medical ICU, we conducted a case-control study with matching for initial severity of illness, with daily monitoring of severity of illness and therapeutic activity scores, and with analysis of the contribution of nosocomial infections to patients' outcomes. Forty-one cases of patients who developed nosocomial infections during a 1-yr period were paired with 41 controls without nosocomial infection according to three criteria: age (+/- 5 yr), Acute Physiology and Chronic Health Evaluation II (APACHE II) score (+/- 5 points), and duration of exposure to risk. Successful matching was achieved for 118 of 123 (96%) variables. Neurologic failure on the third day after ICU admission was the sole independent risk factor for nosocomial infection (adjusted odds ratio [OR]: 1.34; 95% confidence interval [CI]: 1.09 to 1.64; p = 0.007). Unlike control patients, case patients showed no clinical improvement and required a high level of therapeutic activity between ICU admission and the day of infection. Mortality attributable to nosocomial infection was 44%. Excess length of stay and duration of antibiotic treatment attributable to nosocomial infection were 14 d and 10 d, respectively. Attributable therapeutic activity as measured with the Therapeutic Intervention Scoring System (TISS) and Omega score was 368 and 233 points, respectively. Such consequences were observed in patients who developed multiple infections. These findings suggest that a persistent high level of therapeutic activity and persistent impaired consciousness are risk factors for nosocomial infections in ICU patients. These infections are responsible for excess mortality, prolongation of stay, and excess therapeutic activity resulting in important cost overruns for health-care systems.


Assuntos
Infecção Hospitalar/etiologia , Unidades de Terapia Intensiva , APACHE , Idoso , Antibacterianos/uso terapêutico , Estudos de Casos e Controles , Infecção Hospitalar/tratamento farmacológico , Infecção Hospitalar/mortalidade , Feminino , Escala de Coma de Glasgow , Humanos , Tempo de Internação , Masculino , Pessoa de Meia-Idade , Fatores de Risco , Taxa de Sobrevida
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