RESUMO
The sensitivity of ram erythrocyte-specific B-cells to cyclophosphane was studied. An antigen and two polyclonal activators, lipopolysaccharide and dextran sulfate, were used as the clone activators. The immunodepressant effect of cyclophosphane was found to depend on the degree of the immunocompetent clone activation. The maximal elimination of the clone under the influence of cyclophosphane occurred after its activation by the antigen and lipopolysaccharide. The drug exerted the minimal effect on the "resting" clone. The degree of suppression of the clone activated by dextran sulfate took the intermediate position.
Assuntos
Ciclofosfamida/farmacologia , Sistema Imunitário/efeitos dos fármacos , Animais , Células Produtoras de Anticorpos/efeitos dos fármacos , Células Produtoras de Anticorpos/imunologia , Linfócitos B/efeitos dos fármacos , Linfócitos B/imunologia , Sulfato de Dextrana , Dextranos/farmacologia , Eritrócitos/imunologia , Sistema Imunitário/imunologia , Imunização , Terapia de Imunossupressão , Lipopolissacarídeos/farmacologia , Camundongos , Camundongos Endogâmicos CBA , Ovinos/imunologia , Shigella sonnei , Baço/efeitos dos fármacos , Baço/imunologia , Fatores de TempoRESUMO
The study of the effect of a new antitumor drug cortifen on humoral immunity in experiments on CBA mice showed that it is a potent and long acting immunodepressant. The degree of immunity depression was found to be drug dose-dependent. The hormonal components of cortifen failed to exert the immunodepressive action. The alkylating component, chlorphenacyl, on the contrary, had the immunostimulating effect.
