RESUMO
Following oral ingestion of cannabis resin, delta 9-THC-11-oic acid and its O-ester glucuronide were detected using RIA and combined hplc/RIA and shown to be major plasma metabolites of delta 9-THC. delta 9-THC-11-oic acid was not excreted in the urine in significant concentrations, the glucuronide conjugate being the major urinary metabolite detected. delta 9-THC metabolites were detected in blood for up to 5 days and in urine for up to 12 days following a single oral dose of delta 9-THC (20 mg). Estimates for the half life of delta 9-THC-11-oic acid and its glucuronide in plasma, and total metabolites in urine have been obtained. Interpretation of blood or urine total cannabinoid levels is most difficult, however, drug/metabolite ratios and metabolite/metabolite ratios may have potential for indicating recent cannabis use.
Assuntos
Canabinoides/metabolismo , Cannabis , Adulto , Biotransformação , Dronabinol/sangue , Dronabinol/urina , Estabilidade de Medicamentos , Medicina Legal , Humanos , Cinética , Masculino , Radioimunoensaio , Toxicologia/métodosRESUMO
Dimethylsulphoxide (DMSO) induced swelling in guinea pig ears was found to be abolished by H1- and H2-receptor blocking agents. On histological examination of the ears some degranulation of mast cells was seen. It was concluded that the swelling was mediated by histamine release.
Assuntos
Dimetil Sulfóxido/toxicidade , Liberação de Histamina/efeitos dos fármacos , Pele/efeitos dos fármacos , Animais , Orelha/anatomia & histologia , Orelha/efeitos dos fármacos , Edema/induzido quimicamente , Feminino , Cobaias , Pele/metabolismoAssuntos
Glicolatos/uso terapêutico , Gota/tratamento farmacológico , Hipertensão/tratamento farmacológico , Ticrinafeno/uso terapêutico , Adulto , Análise Química do Sangue , Pressão Sanguínea , Creatinina/metabolismo , Gota/complicações , Gota/metabolismo , Humanos , Hipertensão/complicações , Hipertensão/metabolismo , Pessoa de Meia-Idade , Ureia/sangue , Ácido Úrico/metabolismoRESUMO
1 An intravenous injection of cimetidine 400 mg to four healthy male subjects resulted in high blood concentrations of cimetidine and a rapid three-fold increase in serum prolactin. 2 This effect was prevented by pretreatment with bromocriptine. 3 No increase in prolactin followed a single oral dose of cimetidine 800 mg administered to a different group of healthy male subjects. The mean peak blood concentration of cimetidine was less than 20% of that achieved with 400 mg i.v. 4 Only isolated reports have been received of gynaecomastia or galactorrhoea occurring during cimetidine treatment. In three of seven cases studied there was associated hyperprolactinaemia. This may be an idiosyncratic response at the lower blood concentration of cimetidine associated with oral therapeutic dose regimens.
Assuntos
Cimetidina/farmacologia , Guanidinas/farmacologia , Prolactina/sangue , Administração Oral , Bromocriptina/farmacologia , Cimetidina/administração & dosagem , Interações Medicamentosas , Humanos , Injeções Intravenosas , Masculino , Fatores de TempoAssuntos
Anti-Infecciosos Urinários/uso terapêutico , Infecções Urinárias/tratamento farmacológico , Adolescente , Adulto , Idoso , Ampicilina/uso terapêutico , Doença Crônica , Escherichia coli/isolamento & purificação , Infecções por Escherichia coli/complicações , Infecções por Escherichia coli/tratamento farmacológico , Feminino , Hospitalização , Humanos , Masculino , Pessoa de Meia-Idade , Ácido Nalidíxico/uso terapêutico , Nitrofurantoína/uso terapêutico , Pielonefrite/complicações , Sulfametazina/uso terapêutico , Infecções Urinárias/complicações , Infecções Urinárias/diagnóstico , Infecções Urinárias/microbiologia , Urina/microbiologiaAssuntos
Nervos Periféricos/patologia , Doenças do Sistema Nervoso Periférico/etiologia , Uremia/complicações , Adulto , Biópsia , Doenças Desmielinizantes/patologia , Feminino , Humanos , Falência Renal Crônica/patologia , Masculino , Pessoa de Meia-Idade , Degeneração Neural , Neurônios , Uremia/patologiaRESUMO
Plasma renin concentration was increased, usually appreciably, in 22 out of 25 patients with acute renal failure, the average value being 226 units/litre (mean for normal subjects 8.2 units/1.). The highest renin values were found in the first 10 days of the disease; lower and sometimes normal values were found subsequently. Unequivocal acute tubular necrosis was present in only two of the eight cases examined post mortem.These findings are compatible with Goormaghtigh's proposal that an excess of renin and angiotensin may act within the kidney to produce acute renal failure.