[Immunological indices in the differential diagnosis of rheumatic and nonrheumatic carditis]. / Immunologicheskie pokazateli pri differentsial'noi diagnostike revmaticheskikh i nerevmaticheskikh karditov.

The cellular and humoral immunity was studied in 32 children with primary rheumocarditis and 34 children with nonrheumatic carditis. It is shown that there are no distinct diagnostic criteria of rheumatism form with a paucity of symptoms. This gave an impetus to develop a new method of diagnosis of the rheumatic process by means of preincubation of blood lymphocytes of the patient with a standard streptococcal allergen (dose: 0.1 ml, 30-40 mcg of protein) within 30 min. with subsequent realization of E-rosette formation reaction. Of diagnostic value was an increase of the relative content of E-rosette formation by 10% as compared with the control. The positive effect of this method as compared with determination of the antistreptolysin titer--79%. This allows to recommend wide introduction of the method in practical medicine.

[Effect of interferon on the course of experimental E coli-induced pyelonephritis]. / Vliianie interferona na techenie eksperimental'nogo kolibatsilliarnogo pielonefrita.

The effect of the type I interferon on the development and process of experimental pyelonephritis caused by E. coli was studied on mice weighing 12 to 14 g. Interferon was administered intraperitoneally in a dose of 1000 units on days 3 and 7 of the disease. It was shown that the administration of the type I interferon to the mice with experimental pyelonephritis promoted rapid elimination of bacteria from the kidneys, prevented their penetration to the contralateral (intact) kidney, prevented marked macro- and microscopic damages in the kidneys, lowered the intensity of the inflammatory reaction, and increased the phagocytic activity of neutrophils and the number of the E-rosette-forming lymphocytes in the thymus. The data provided experimental grounding for clinical trials of interferon preparations in treatment of bacterial pyelonephritis.

[Interferon in the modulation of the immune response in pyelonephritis caused by Staphylococci and Pseudomonas aeruginosa]. / Interferon v moduliatsii immunnogo otveta pri stafilokokkovom i sinegnoinom pielonefrite.

In experiments on mice the influence of mouse serum interferon, type I, on immune response in pyelonephritis caused by staphylococci and P. aeruginosa has been studied. The immunomodulating action of interferon and its therapeutic effectiveness have been shown to depend on the etiology of the disease. When injected intraperitoneally in a dose of 1,000 ED, interferon produces a pronounced therapeutic effect in pyelonephritis caused by P. aeruginosa and no effect in pyelonephritis of staphylococcal etiology. Type I interferon introduced in the dose used in this investigation has no influence on the killer activity of spleen lymphocytes, enhances the activity of the complement and the production of antibodies, produces a leukopenic effect and, depending on the etiology of pyelonephritis, exerts influence on the activity of dehydrogenases, the number of EAC- and E-rosette-forming cells, the oxidation metabolism of neutrophils and their phagocytic activity.