1.
[Interaction of DNA with actinocyl-bis-thiazole]. / Vzaimodeistvie DNK s aktinoatsil-bis-bitiazolom.
Mol Biol (Mosk)
; 29(1): 144-8, 1995.
Artigo
em Russo
| MEDLINE
| ID: mdl-7723754
RESUMO
The DNA complexes with actinocyl-bis-bithiazole have been investigated by spectrophotometry, viscometry and flow birefringence. It was estimated, that at low degrees of binding (r < or = 0.07) this compound binds to DNA by bisintercalation via bithiazole groups located in positions 1 and 9 of the phenoxazone chromophore. The phenoxazone moiety plays in this case the role of a link connecting two intercalating fragments. As r increases, external groove binding becomes the second type of complex formation.