[Clinical value of changes in red blood cell ultrastructure and energy metabolism in children with cystic fibrosis].

In 42 patients of various age (from 1 month to 14 years) with cystic fibrosis were analyzed ultra structure, level of adenylnucleotides and activity ATP-ase of erythrocytes, in order to characterize their membrane and energy metabolism. The studies revealed the changes in erythrocytes in the cases of cystic fibrosis. In the cases of broncho pulmonary form of cystic fibrosis were detected I and II row echinocytes, cone-shaped erythrocytes, also erythrocytes with reach-through hole in center. At mixed form of cystic fibrosis were detected more changes in erythrocytes than in other forms of this disease. Both cone-shaped erythrocytes were more than in other forms of cystic fibrosis. Also there were detected erythrocytes with holes (round, polygonal) in their center. The results of the study provide a more precise diagnosis, in time correction of disorders and a comprehensive assessment of multiple-modality treatment of cystic fibrosis.

[Prevalence of minimal thyroid deficiency (subclinical hypothyreosis) and subclinical thireotoxicosis among females of average and elderly ages who hadn't been examined before].

Adjara is a region in Georgia with high level at iodine deficiency. The research has been carried out to find subclinical dysfunctions of thyroid gland in women older than 40 years whose thyroid state hadn't been examined before. From 1998 to 2004 583 women aged 40-78 had been examined. Primary examination was done by different specialists. All women were tested on thyreotropic hormone (TSH) by means of immunodiagnostic unit "Digiscan SD-1000" (Austria). Examination of thyroid gland on the unit Philips SD-800 was done to estimate the volume and echological structure. The patients with raised level of TSH (more than 4,1) and lowered level of TSH (less 0,3) had undergone additional testing on free T4 and titers of antibodies to thyreoglobulin and thyreoperoxidase. All patients were divided according to their age. The 1st group n=289 from 40 to 55 (average age 44+/-1,3) and the 2nd group n=294 from 56 to 78 (average age 61,5+/-2,3). High frequency of subclinical hypothyreosis has been found in women from the first group 7,9 % as well as in the second group--17,7 %. Higher frequency of subclinical hypothyreosis was associated with the older age (p<0,001). In the first group the level of subclinical thyreotoxicosis was lower- 2,2 % and in the second group- 4,1 %. Higher frequency of subclinical hypothyreosis was associated with the older age as well.